Pilot trial of N-acetylcysteine and tigecycline as a catheter-lock solution for treatment of hemodialysis catheter-associated bacteremia

被引：22

作者：

Aslam, Saima ^{[1
,2
]}

Trautner, Barbara W. ^{[2
]}

Ramanathan, Venkat ^{[3
]}

Darouiche, Rabih O. ^{[2
,4
]}

机构：

[1] Michael E DeBakey VA Med Ctr, Infect Dis Sect, Houston, TX 77030 USA

[2] Baylor Coll Med, Infect Dis Sect, Dept Med, Houston, TX 77030 USA

[3] Baylor Coll Med, Nephrol Sect, Dept Med, Houston, TX 77030 USA

[4] Baylor Coll Med, Ctr Prostheses Infect, Houston, TX 77030 USA

来源：

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY | 2008年 / 29卷 / 09期

关键词：

D O I：

10.1086/590192

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We evaluated a catheter-lock solution consisting of N-acetylcysteine, tigecycline, and heparin for catheter salvage in patients with hemodialysis catheter-associated bacteremia. Eighteen case patients received the catheter-lock solution for 14 days plus systemic antibiotic therapy. Treatment was successful for 15 (83%) of the 18 case patients within 90 days of follow-up, with a median catheter retention interval of 64.5 days.

引用

页码：894 / 897

页数：4

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