cDNA micro array identification of a gene differentially expressed in adenovirus type 5-versus type 12-transformed cells

被引：10

作者：

Vertegaal, ACO ^{[1
]}

Kuiperij, HB ^{[1
]}

van Laar, T ^{[1
]}

Scharnhorst, V ^{[1
]}

van der Eb, AJ ^{[1
]}

Zantema, A ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, MGC Dept Mol Cell Biol, Mol Carcinogenesis Lab, NL-2333 AL Leiden, Netherlands

来源：

FEBS LETTERS | 2000年 / 487卷 / 02期

关键词：

follistatin-related protein; adenovirus; transformation; cDNA micro array; Wilms tumor; TGF-beta;

D O I：

10.1016/S0014-5793(00)02339-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteins encoded by non-oncogenic adenovirus type 5 and oncogenic adenovirus type 12 differentially affect expression of a number of cellular genes. We have used cDNA micro array analysis to identify a cellular gene that is expressed in Ad12- but not in Ad5-transformed cells. This cellular gene mas found to be the gene encoding follistatin-related protein, a TGF-beta inducible gene, Consistently, a constitutive factor binding to Smad binding elements was found in adenovirus type 12-transformed cells. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

收藏

页码：151 / 155

页数：5

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