Different molecular weight chitosan microspheres: Influence on drug loading and drug release

被引：49

作者：

Genta, I ^{[1
]}

Perugini, P ^{[1
]}

Pavanetto, F ^{[1
]}

机构：

[1] Univ Pavia, Dept Pharmaceut Chem, I-27100 Pavia, Italy

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1998年 / 24卷 / 08期

关键词：

D O I：

10.3109/03639049809082726

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Influence of chitosan molecular weight on drug loading and drug release of drug-loaded chitosan microspheres was studied. Chitosans of 70,000 (LC), 750,000 (MC), and 2, 000, 000 (HC) molecular weight were employed alone or as mixtures (HC/LC 1:1-1:2 w/w). Ketoprofen (ket) was chosen as the model drug to be encapsulated. Microspheres characterized by different theoretical polymer/drug ratios were prepared (2:1, 1:1, 1:2 w/w). Satisfactory ket contents were obtained for all batches of chitosan microspheres with the theoretical polymer/drug ratio 1:2 w/ w; microspheres made of HC/LC (1:2 w/w) were characterized by good drug content and encapsulation efficiency independent by polymer/drug ratio. Prepared chitosan microparticulate delivery systems can modulate ket release within 48 hr. Microspheres consisting of HC/LC (1:2 w/w) were the most suitable formulation in controlling drug release.

引用

页码：779 / 784

页数：6