Genetic susceptibility factors for Alzheimer's disease

被引:68
作者
Richard, F [1 ]
Amouyel, P [1 ]
机构
[1] Inst Pasteur Lille, INSERM 508, F-59019 Lille, France
关键词
Alzheimer's disease; gene environment interaction; genetic susceptibility factor; apolipoprotein E;
D O I
10.1016/S0014-2999(00)00903-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Alzheimer's disease is the most frequent cause of dementia. Family and twin studies have suggested that genetic factors play a role in Alzheimer's disease development. Some Alzheimer's disease cases show an autosomal dominant inheritance pattern and thus allow the discovery of major disease genes. However, most Alzheimer's disease cases are sporadic. These cases are mainly due to the effects of several different genes and of interactions between genetic susceptibility factors and environmental factors. Such interactions are illustrated by the apolipoprotein E epsilon4 allele, associated with a higher risk of Alzheimer's disease. Other genetic susceptibility factors have been reported but variously confirmed in Alzheimer's disease: apolipoprotein E receptors, alpha 2-macroglobulin or angiotensin I converting enzyme genes. Thus, except for a small percentage of Alzheimer's disease cases with a dominant inheritance pattern, the genetic component of the vast majority of cases is underlain by complex interactions of genetic susceptibility factors and environmental conditions. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:1 / 12
页数:12
相关论文
共 123 条
[81]   GENETIC ASSOCIATION OF THE VERY-LOW-DENSITY LIPOPROTEIN (VLDL) RECEPTOR GENE WITH SPORADIC ALZHEIMERS-DISEASE [J].
OKUIZUMI, K ;
ONODERA, O ;
NAMBA, Y ;
IKEDA, K ;
YAMAMOTO, T ;
SEKI, K ;
UEKI, A ;
NANKO, S ;
TANAKA, H ;
TAKAHASHI, H ;
OYANAGI, K ;
MIZUSAWA, H ;
KANAZAWA, I ;
TSUJI, S .
NATURE GENETICS, 1995, 11 (02) :207-209
[82]   Angiotensin converting enzyme deletion allele in different kinds of dementia disorders [J].
Palumbo, B ;
Cadini, D ;
Nocentini, G ;
Filipponi, E ;
Fravolini, ML ;
Senin, U .
NEUROSCIENCE LETTERS, 1999, 267 (02) :97-100
[83]   Complete genomic screen in late-onset familial Alzheimer disease - Evidence for a new locus on chromosome 12 [J].
PericakVance, MA ;
Bass, MP ;
Yamaoka, LH ;
Gaskell, PC ;
Scott, WK ;
Terwedow, HA ;
Menold, MM ;
Conneally, PM ;
Small, GW ;
Vance, JM ;
Saunders, AM ;
Roses, AD ;
Haines, JL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (15) :1237-1241
[84]   Deletion polymorphism of angiotensin-converting enzyme gene and left ventricular hypertrophy in Southern Italian patients [J].
Perticone, F ;
Ceravolo, R ;
Cosco, C ;
Trapasso, M ;
Zingone, A ;
Malatesta, P ;
Perrotti, N ;
Tramontano, D ;
Mattioli, PL .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1997, 29 (02) :365-369
[85]   Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease [J].
Poirier, J ;
Delisle, MC ;
Quirion, R ;
Aubert, I ;
Farlow, M ;
Lahiri, D ;
Hui, S ;
Bertrand, P ;
Nalbantoglu, J ;
Gilfix, BM ;
Gauthier, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (26) :12260-12264
[86]   No association between very low density lipoprotein receptor (VLDL-R) and Alzheimer disease in American Caucasians [J].
Pritchard, ML ;
Saunders, AM ;
Gaskell, PC ;
Small, GW ;
Conneally, PM ;
Rosi, B ;
Yamaoka, LH ;
Roses, AD ;
Haines, JL ;
PericakVance, MA .
NEUROSCIENCE LETTERS, 1996, 209 (02) :105-108
[87]   Alzheimer's disease in Finnish twins [J].
Raiha, I ;
Kaprio, J ;
Koskenvuo, M ;
Rajala, T ;
Sourander, L .
LANCET, 1996, 347 (9001) :573-578
[88]   Galantamine in AD - A 6-month randomized, placebo-controlled trial with a 6-month extension [J].
Raskind, MA ;
Peskind, ER ;
Wessel, T ;
Yuan, W .
NEUROLOGY, 2000, 54 (12) :2261-2268
[89]   MULTIPLE, DIVERSE SENILE PLAQUE-ASSOCIATED PROTEINS ARE LIGANDS OF AN APOLIPOPROTEIN-E RECEPTOR, THE ALPHA(2)-MACROGLOBULIN RECEPTOR LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN [J].
REBECK, GW ;
HARR, SD ;
STRICKLAND, DK ;
HYMAN, BT .
ANNALS OF NEUROLOGY, 1995, 37 (02) :211-217
[90]  
REBECK GW, 1993, NEURON, V11, P575