Oxidative stress in diabetes

被引：173

作者：

Piconi, L

Quagliaro, L

Ceriello, A

机构：

[1] Univ Udine, Chair Internal Med, I-33100 Udine, Italy

[2] Univ Udine, Dept Pathol & Med Expt & Clin, I-33100 Udine, Italy

[3] Morpurgo Hofman Res Lab Aging, Udine, Italy

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2003年 / 41卷 / 09期

关键词：

oxidative stress markers; diabetes; 8-hydroxy-2 '-dexoyguanosine; malondialdehyde; nitrotyrosine;

D O I：

10.1515/CCLM.2003.177

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Increasing evidence in both experimental and clinical studies suggests that there is a close link between hyperglycemia, oxidative stress and diabetic complications. High blood glucose level determines overproduction of reactive oxygen species (ROS) by the mitochondria electron transport chain. High reactivity of ROS determines chemical changes in virtually all cellular components, leading to DNA and protein modification and lipid peroxidation. Measurement of biomarkers such 8-hydroxy-2deoxyguanosine (8-OHdG), isoprostanes, malondialdehyde (MDA) and nitrotyrosine is a useful tool to assess the oxidative stress of the organism. Knowledge of the mechanisms of ROS damage of is the first step for development of new therapeutic molecules and for rationalizing the use of existing drugs.

引用

页码：1144 / 1149

页数：6

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