Characterization of a dengiie patient cohort in Recife, Brazil

被引：70

作者：

Cordeiro, Marli Tenorio ^{[1
,2
]}

Silva, Ana Maria ^{[1
]}

Brito, Carlos A. A. ^{[1
,4
]}

Nascimento, Eduardo J. M. ^{[1
,3
]}

Magalhaes, Maria Cecilia F. ^{[1
]}

Guimaraes, Georgia F. ^{[1
]}

Lucena-Silva, Norma ^{[5
]}

Freese de Carvalho, Eduardo M. ^{[6
]}

Marques, Ernesto T. A., Jr.

机构：

[1] CPqAM, Lab Virol & Terapia Expt, BR-50670420 Recife, PE, Brazil

[2] Estado Pernambuco, Secretaria Saude, Lab Cent Saude Publ, BR-50050210 Recife, PE, Brazil

[3] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[4] Univ Fed Pernambuco, Hosp Esperanca, Dept Clin Med, Recife, PE, Brazil

[5] Ctr Pesquisas Aggeu Magalhaes, Dept Imunol, BR-50670420 Recife, PE, Brazil

[6] Ctr Pesquisas Aggeu Magalhaes, Dept Saude Coletiva, BR-50670420 Recife, PE, Brazil

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2007年 / 77卷 / 06期

关键词：

D O I：

10.4269/ajtmh.2007.77.1128

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

From 2004 to 2006, 658 patients with suspected dengue virus infections were enrolled in a clinical dengue cohort established in Recife, Pernambuco, located at the northeastern region of Brazil. A total of 2,364 blood samples were collected, and serum, plasma, and cells were cryopreserved. Among the suspected cases, 354 (54%) were confirmed as acute DENV-3 infection based on reverse transcription-polymerase chain reaction, virus isolation, and ELISA-IgM. According to WHO criteria, 29.4% of the positive acute cases were classified as dengue fever (DF) and 8.2% of the cases as dengue hemorrhagic fever (DHF), grade 1 or 2. The DHF cases represent 100% of those confirmed in Recife during the period of the study. The dengue cases that did not fulfill the definition of either DHF or DF were classified as DF complicated and accounted for 44.0% of the cases. All the acute cases were classified as either primary or secondary acute dengue virus infections. Secondary infection was predominant in patients with DF; however, there was no predominance of either primary or secondary infections in patients with DHF.

引用

页码：1128 / 1134

页数：7

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