Aminocyclitols as pharmacological chaperones for glucocerebrosidase, a defective enzyme in Gaucher disease

被引：32

作者：

Egido-Gabas, Meritxell

Canals, Daniel

Casas, Josefina

Llebaria, Amadeu

Delgado, Antonio

机构：

[1] Research Unit on Bioactive Molecules (RUBAM), Departament de Química Orgànica Biològica, Institut d'Investigacions Químiques I Ambientals de Barcelona (IIQAB-C.S.I.C), 08034 Barcelona

[2] Universitat de Barcelona, Facultat de Farmàcia, Unitat de Química Farmacèutica (Unitat Associada al CSIC), 08028 Barcelona, Avda. Joan XXIII, s/n

来源：

CHEMMEDCHEM | 2007年 / 2卷 / 07期

关键词：

D O I：

10.1002/cmdc.200700061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Chemical Equation Presented) New therapeutic strategies against sphingolipidoses: a series of aminocyclitols described herein represent new structural types of compounds with promising chaperone-like properties on GlcCerase, a defective enzyme associated with Gaucher disease. © 2007 Wiley-VCH Verlag GmbH& Co. KGaA.

引用

页码：992 / 994

页数：3

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