Gene-encoded peptide antibiotics and innate immunity. Do 'animalcules' have defence budgets?

被引：50

作者：

Barra, D

Simmaco, M

Boman, HG

机构：

[1] Univ Rome La Sapienza, Ist Pasteur, Fdn Cenci Bolognetti, Dipartimento Sci Biochim A Rossi Fanelli, I-00185 Rome, Italy

[2] Univ Rome La Sapienza, CNR, Ctr Biol Mol, I-00185 Rome, Italy

[3] Univ Chieti, Dipartimento Sci Biomed, I-66100 Chieti, Italy

[4] Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden

来源：

FEBS LETTERS | 1998年 / 430卷 / 1-2期

关键词：

peptide antibiotic; innate immunity; NF kappa B-I kappa B; glucocorticoid; amphibian; Rana esculenta;

D O I：

10.1016/S0014-5793(98)00494-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene-encoded peptide antibiotics have been isolated from plants, animals and microbes. Their protective role has been related to innate immunity, which has gradually become accepted across the biomedical community, The evidence for the immune function of peptide antibiotics has been convincingly demonstrated by a combination of both in vitro and in vivo data for plants and insects, but for vertebrates in vivo data are scarce. Using frogs as model systems, it has been shown that the genes for antibacterial peptides are down-regulated by glucocorticoids, while I kappa B alpha is clearly up-regulated, Experimental infections with frog bacteria have shown that the normal capacity to control the natural flora is lost after treatment with glucocorticoids, A low-specificity immune mechanism is cost-effective, something that may have been of importance during animal evolution. (C) 1998 Federation of European Biochemical Societies.

引用

页码：130 / 134

页数：5

共 43 条

[11]

FRANK RW, 1990, J BIOL CHEM, V265, P18871

[12] SYNDECANS, CELL-SURFACE HEPARAN-SULFATE PROTEOGLYCANS, ARE INDUCED BY A PROLINE-RICH ANTIMICROBIAL PEPTIDE FROM WOUNDS [J].

GALLO, RL ;

ONO, M ;

POVSIC, T ;

PAGE, C ;

ERIKSSON, E ;

KLAGSBRUN, M ;

BERNFIELD, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (23) :11035-11039

[13]

GIBSON BW, 1991, J BIOL CHEM, V266, P23103

[14] BIOSYNTHESIS AND DEGRADATION OF PEPTIDES DERIVED FROM XENOPUS-LAEVIS PROHORMONES [J].

GIOVANNINI, MG ;

POULTER, L ;

GIBSON, BW ;

WILLIAMS, DH .

BIOCHEMICAL JOURNAL, 1987, 243 (01) :113-120

[15] Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis [J].

Goldman, MJ ;

Anderson, GM ;

Stolzenberg, ED ;

Kari, UP ;

Zasloff, M ;

Wilson, JM .

CELL, 1997, 88 (04) :553-560

[16] The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes [J].

Gudmundsson, GH ;

Agerberth, B ;

Odeberg, J ;

Bergman, T ;

Olsson, B ;

Salcedo, R .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 238 (02) :325-332

[17] STRUCTURE OF THE GENE FOR PORCINE PEPTIDE ANTIBIOTIC PR-39, A CATHELIN GENE FAMILY MEMBER - COMPARATIVE MAPPING OF THE LOCUS FOR THE HUMAN PEPTIDE ANTIBIOTIC FALL-39 [J].

GUDMUNDSSON, GH ;

MAGNUSSON, KP ;

CHOWDHARY, BP ;

JOHANSSON, M ;

ANDERSSON, L ;

BOMAN, HG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (15) :7085-7089

[18] Drosophila immunity [J].

Hoffmann, JA ;

Reichhart, JM .

TRENDS IN CELL BIOLOGY, 1997, 7 (08) :309-316

[19] The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1 [J].

Huttner, KM ;

Kozak, CA ;

Bevins, CL .

FEBS LETTERS, 1997, 413 (01) :45-49

[20] Homology between immune responses in vertebrates and invertebrates: Does it exist? [J].

Klein, J .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1997, 46 (06) :558-564

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