Increased urinary leukotriene E4 excretion in patients with atopic dermatitis

被引：24

作者：

Hishinuma, T ^{[1
]}

Suzuki, N ^{[1
]}

Aiba, S ^{[1
]}

Tagami, H ^{[1
]}

Mizugaki, M ^{[1
]}

机构：

[1] Tohoku Univ, Sch Med, Dept Dermatol, Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2001年 / 144卷 / 01期

关键词：

atopic dermatitis; IgE; leukotriene E-4; liquid chromatography; tandem mass spectrometry;

D O I：

10.1046/j.1365-2133.2001.03947.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background Synthesis of cysteinyl leukotrienes (LTs) is known to play a part in the pathogenesis of inflammatory diseases. Objectives To define the involvement of cysteinyl LTs in atopic dermatitis (AD). Methods Synthesis of cysteinyl LTs was assessed in patients with AD and healthy volunteers by measuring urinary LTE4, a useful index of systemic cysteinyl LT synthesis, using liquid chromatography/tandem mass spectrometry. Results Mean +/- SD urinary LTE4 levels in patients with AD (125 +/- 69 pg mg(-1) creatinine, n = 20) were significantly higher (P < 0.01) than in healthy volunteers (60 +/- 19 pg mg(-1) creatinine, n = 17). A significant correlation between urinary LTE4 and total serum IgE levels in patients with AD was observed (r = 0.643, P < 0.05). Conclusions Our findings demonstrate an enhanced synthesis of cysteinyl LTs in patients with AD and suggest that cysteinyl LTs are involved in the pathophysiology of AD.

引用

页码：19 / 23

页数：5

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