Galectin-1 Enhances Astrocytic BDNF Production and Improves Functional Outcome in Rats Following Ischemia

被引：63

作者：

Qu, Wen-sheng ^{[1
]}

Wang, Yi-hui ^{[1
]}

Wang, Jian-ping ^{[2
]}

Tang, Ying-xin ^{[1
]}

Zhang, Qiang ^{[1
]}

Tian, Dai-shi ^{[1
]}

Yu, Zhi-yuan ^{[1
]}

Xie, Min-jie ^{[1
]}

Wang, Wei ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Neurol, Wuhan 430030, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 5, Dept Neurol, Zhengzhou 450000, Peoples R China

来源：

NEUROCHEMICAL RESEARCH | 2010年 / 35卷 / 11期

关键词：

Cerebral ischemia; Galectin-1; Brain derived neurotrophic factor; Astrocyte; NEURAL STEM-CELLS; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE; NERVOUS-SYSTEM; BRAIN; EXPRESSION; RECOVERY; INJURY; PROTEINS; PROLIFERATION;

D O I：

10.1007/s11064-010-0234-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Galectin-1, an endogenous mammalian lectin, has been implicated in a variety of CNS disorders. However, its role in cerebral ischemia is still elusive. In the present study, we investigated the effect of recombinant galectin-1 on production of astrocytic brain-derived neurotrophic factor (BDNF) and functional recovery following ischemia. Endogenous galectin-1 was found to be markedly upregulated, paralleled with increased astrocytic BDNF production under ischemic conditions both in vitro and in vivo. Administration of galectin-1significantly enhanced the expression and secretion of astrocytic BDNF in dose dependent manner. Moreover, rats subjected to photochemical cerebral ischemia showed reduced neuronal apoptosis in ischemic boundary zone and improved functional recovery after brain infusion of galectin-1 (1 mu g/days, 7 days). These results suggest that induction of BDNF in astrocytes by galectin-1 may be a promising intervention to attenuate brain damage after stroke.

引用

页码：1716 / 1724

页数：9

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