Creating immune privilege: active local suppression that benefits friends, but protects foes

被引：254

作者：

Mellor, Andrew L.

Munn, David H.

机构：

[1] Andrew L. Mellor and David H. Munn are at the Immunotherapy and Cancer Centers,

[2] Medical College of Georgia,undefined

[3] Augusta,undefined

[4] Georgia USA.,undefined

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 01期

关键词：

D O I：

10.1038/nri2233

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How do antigenic tumour cells and chronic pathogens exploit natural regulatory mechanisms to become non-immunogenic? Andrew Mellor and David Munn propose that such immune unresponsiveness is an indirect consequence of the need to control the potentially lethal consequences of unrestrained immunity to innocuous substances.

引用

收藏

页码：74 / 80

页数：7

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