In situ synthesis and magnetic studies of iron oxide nanoparticles in calcium-alginate matrix for biomedical applications

被引：67

作者：

Morales, M. A. ^{[1
]}

Finotelli, P. V. ^{[1
]}

Coaquira, J. A. H. ^{[2
]}

Rocha-Leao, M. H. M. ^{[3
]}

Diaz-Aguila, C. ^{[4
]}

Baggio-Saitovitch, E. M. ^{[2
]}

Rossi, A. M. ^{[2
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Quim, BR-21949900 Rio De Janeiro, Brazil

[2] Ctr Brasileiro Pesquisas Fis, BR-22290180 Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, Escola Quim, BR-21949900 Rio De Janeiro, Brazil

[4] Univ La Habana, Ctr Biomat, Havana, Cuba

来源：

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2008年 / 28卷 / 02期

关键词：

alginate; iron oxide nanoparticles; biopolymer; electron paramagnetic resonance; Mossbauer spectroscopy;

D O I：

10.1016/j.msec.2006.12.016

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In this work we applied a new route to synthesize magnetic iron oxide nanoparticles into alginate polymer for future application as drug delivery system activated by magnetic external stimuli. Calcium-alginate was used to encapsulate iron oxide nanoparticles, and as scaffold for particle nucleation and its influence on particles size and magnetic properties were studied. The iron oxide mean sizes were between 4.3 and 9.5 nm. Iron is dispersed throughout the polymer matrix mainly as iron oxide particles, and a small fraction as iron (III) occupying calcium sites in the polymer network. The temperature dependence of the Mossbauer spectra is typical of superparamagnetic particles in agreement with the magnetic susceptibility data. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：253 / 257

页数：5

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