Hierarchically nanostructured magnetic hollow spheres of Fe3O4 and γ-Fe2O3:: Preparation and potential application in drug delivery

被引:345
作者
Cao, Shao-Wen [1 ,2 ]
Zhu, Ying-Jie [1 ,2 ]
Ma, Ming-Yan [1 ,2 ]
Li, Liang [1 ,2 ]
Zhang, Ling [1 ,2 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China
关键词
D O I
10.1021/jp077468+
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We report for the first time a novel precursor-templated conversion method for the controlled synthesis of hierarchically nanostructured magnetic hollow spheres assembled by Fe3O4 or gamma-Fe2O3 nanosheets with a relatively high saturation magnetization. We synthesized hierarchically nanostructured hollow spheres organized by nanosheets of a layer-structured ferrous precursor by a microwave-assisted hydrothermal method in ethylene glycol (EG). Ferric chloride (FeCl3 center dot 6H(2)O) was used as the iron source, and EG acted as both a solvent and a reductant to reduce ferric salt to ferrous precursor in the presence of sodium hydroxide (NaOH) and sodium dodecyl benzene sulfonate (SDBS). The precursor was heated to prepare hierarchically nanostructured magnetic hollow spheres assembled by Fe3O4 or gamma-Fe2O3 nanosheets, which were surface-modified with poly(ethylene glycol) (PEG). The surface-modified hierarchically nanostructured magnetic hollow spheres Were explored as drug carriers. A typical anti-inflammatory drug, ibuprofen, was used for drug loading, and the release behaviors of ibuprofen in a simulated body fluid (SBF) were studied. The results indicate that these hierarchically nanostructured magnetic hollow spheres of Fe3O4 or gamma-Fe2O3 have a high drug loading capacity and favorable release property for ibuprofen; thus, they are very promising for application in drug delivery. The samples were characterized by XRD, TEM, SEM, TG/DSC, BET, PPMS, FTIR, and UV-vis.
引用
收藏
页码:1851 / 1856
页数:6
相关论文
共 36 条
  • [21] Synthesis of maghemite sub-microspheres by simple solvothermal reduction method
    Liu, Xian-Ming
    Fu, Shao-Yun
    Xiao, Hong-Mei
    [J]. JOURNAL OF SOLID STATE CHEMISTRY, 2006, 179 (05) : 1554 - 1558
  • [22] Synthesis of Fe oxide core/Au shell nanoparticles by iterative hydroxylamine seeding
    Lyon, JL
    Fleming, DA
    Stone, MB
    Schiffer, P
    Williams, ME
    [J]. NANO LETTERS, 2004, 4 (04) : 719 - 723
  • [23] Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins
    Nam, JM
    Thaxton, CS
    Mirkin, CA
    [J]. SCIENCE, 2003, 301 (5641) : 1884 - 1886
  • [24] Sonochemical deposition of air-stable iron nanoparticles on monodispersed carbon spherules
    Pol, VG
    Motiei, M
    Gedanken, A
    Calderon-Moreno, J
    Mastai, Y
    [J]. CHEMISTRY OF MATERIALS, 2003, 15 (06) : 1378 - 1384
  • [25] Preparation and characterization of porous ultrafine Fe2O3 particles
    Qiu, J
    Yang, R
    Li, M
    Jiang, N
    [J]. MATERIALS RESEARCH BULLETIN, 2005, 40 (11) : 1968 - 1975
  • [26] Field-directed self-assembly of magnetic nanoparticles
    Sahoo, Y
    Cheon, M
    Wang, S
    Luo, H
    Furlani, EP
    Prasad, PN
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (11) : 3380 - 3383
  • [27] Magnetic nanotubes for magnetic-field-assisted bioseparation, biointeraction, and drug delivery
    Son, SJ
    Reichel, J
    He, B
    Schuchman, M
    Lee, SB
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (20) : 7316 - 7317
  • [28] One-pot synthesis and bioapplication of amine-functionalized magnetite nanoparticles and hollow nanospheres
    Wang, Leyu
    Bao, Jie
    Wang, Lun
    Zhang, Fang
    Li, Yadong
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2006, 12 (24) : 6341 - 6347
  • [29] A solution-phase, precursor route to polycrystalline SnO2 nanowires that can be used for gas sensing under ambient conditions
    Wang, YL
    Jiang, XC
    Xia, YN
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (52) : 16176 - 16177
  • [30] Magnetic control of electrocatalytic and bioelectrocatalytic processes
    Willner, I
    Katz, E
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (38) : 4576 - 4588