The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin

被引:124
作者
Draude, G [1 ]
Hrboticky, N [1 ]
Lorenz, RL [1 ]
机构
[1] Univ Munich, Inst Prophylaxis & Epidemiol Cardiovasc Dis, D-80336 Munich, Germany
关键词
arteriosclerosis; scavenger receptor; oxLDL; LOX-1; lovastatin; monocytes;
D O I
10.1016/S0006-2952(98)00313-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Accumulation of oxidatively modified low-density lipoprotein (oxLDL) in the vascular wall is a characteristic feature of atherosclerosis. oxLDL can be taken up into monocytes, smooth muscle cells, and endothelial cells by several known scavenger receptors such as scavenger receptor class A I and II, CD36, and CD68. A new lectin like oxLDL receptor (LOX-1) was recently found in bovine and human endothelial cells. We studied whether LOX-1 is also expressed in other cells present in the atherosclerotic lesion and whether its expression can be modified. We found LOX-1 expression in human blood monocytes, umbilical smooth muscle and endothelial cells, and 3T3 fibroblasts. LOX-1 mRNA expression in monocytes could be significantly suppressed by lovastatin. Thus, LOX-1 expression is not restricted to endothelial cells and its down-regulation by HMG-CoA reductase inhibitors could contribute to the clinical benefits of these drugs. (C) 1999 Elsevier Science Inc.
引用
收藏
页码:383 / 386
页数:4
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