The Lipogenesis Pathway as a Cancer Target

被引：127

作者：

Abramson, Hanley N. ^{[1
]}

机构：

[1] Wayne State Univ, Eugene Applebaum Coll Pharm & Hlth Sci, Dept Pharmaceut Sci, Detroit, MI 48201 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 16期

关键词：

FATTY-ACID SYNTHASE; ATP-CITRATE LYASE; ACETYL-COA CARBOXYLASE; COENZYME-A CARBOXYLASE; PROSTATE-CANCER; CARBOXYLTRANSFERASE DOMAIN; THIOESTERASE DOMAIN; CRYSTAL-STRUCTURE; HUMAN-BREAST; LIPID-SYNTHESIS;

D O I：

10.1021/jm2005805

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：5615 / 5638

页数：24

共 187 条

[61] Peroxisome proliferator-activated receptor-γ protects ERBB2-positive breast cancer cells from palmitate toxicity [J].

Kourtidis, Antonis ;

Srinivasaiah, Rekha ;

Carkner, Richard D. ;

Brosnan, M. Julia ;

Conklin, Douglas S. .

BREAST CANCER RESEARCH, 2009, 11 (02)

[62]

Kridel SJ, 2004, CANCER RES, V64, P2070, DOI 10.1158/0008-5472.CAN-03-3645

[63] FATTY-ACID SYNTHESIS - A POTENTIAL SELECTIVE TARGET FOR ANTINEOPLASTIC THERAPY [J].

KUHAJDA, FP ;

JENNER, K ;

WOOD, FD ;

HENNIGAR, RA ;

JACOBS, LB ;

DICK, JD ;

PASTERNACK, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6379-6383

[64] Synthesis and antitumor activity of an inhibitor of fatty acid synthase [J].

Kuhajda, FP ;

Pizer, ES ;

Li, JN ;

Mani, NS ;

Frehywot, GL ;

Townsend, CA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3450-3454

[65] Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology [J].

Kuhajda, FP .

NUTRITION, 2000, 16 (03) :202-208

[66] The 10t,12c Isomer of Conjugated Linoleic Acid Inhibits Fatty Acid Synthase Expression and Enzyme Activity in Human Breast, Colon, and Prostate Cancer Cells [J].

Lau, Dominic S. Y. ;

Archer, Michael C. .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2010, 62 (01) :116-121

[67] A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis [J].

Levert, KL ;

Waldrop, GL ;

Stephens, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (19) :16347-16350

[68] Structure-activity relationship of polyphenols that inhibit fatty acid synthase [J].

Li, BH ;

Ma, XF ;

Wang, Y ;

Tian, WX .

JOURNAL OF BIOCHEMISTRY, 2005, 138 (06) :679-685

[69] Inhibitory effects of flavonoids on animal fatty acid synthase [J].

Li, BH ;

Tian, WX .

JOURNAL OF BIOCHEMISTRY, 2004, 135 (01) :85-91

[70] 2-Hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors [J].

Li, James J. ;

Wang, Haixia ;

Tino, Joseph A. ;

Robl, Jeffrey A. ;

Herpin, Timothy F. ;

Lawrence, R. Michael ;

Biller, Scott ;

Jamil, Haris ;

Ponticiello, Randy ;

Chen, Luping ;

Chu, Ching-hsuen ;

Flynn, Neil ;

Cheng, Dong ;

Zhao, Rulin ;

Chen, Bangchi ;

Schnur, Dora ;

Obermeier, Mary T. ;

Sasseville, Vito ;

Padmanabha, Ramesh ;

Pike, Kristen ;

Harrity, Thomas .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (11) :3208-3211

← 2 3 4 5 6 7 8 9 10 11 →