Viral immunosumpression: disabling the guards

被引：9

作者：

Colonna, M ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 05期

关键词：

D O I：

10.1172/JCI200421166

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

When facing an immune response, viruses can either attempt to elude them or confront them. A new report demonstrates that a lymphocytic choriomeningitis virus (LCMV) strain can suppress immune responses by targeting both development and activation of DCs (see the related article beginning on page 737). Ironically, type I IFN released in response to LCMV infection contributes to the blockade of DC development. The discovery of these immunosuppressive mechanisms provides new perspectives for the therapy of chronic infections associated with immunosuppression.

引用

页码：660 / 662

页数：3

共 20 条

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