Stress-induced enhancement of colitis in rats: CRF and arginine vasopressin are not involved

被引：113

作者：

Gue, M ^{[1
]}

Bonbonne, C ^{[1
]}

Fioramonti, J ^{[1
]}

More, J ^{[1
]}

DelRioLacheze, C ^{[1
]}

Comera, C ^{[1
]}

Bueno, L ^{[1
]}

机构：

[1] INST RECH JOUVEINAL, F-94265 FRESNES, FRANCE

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 1997年 / 272卷 / 01期

关键词：

2,4,6-trinitrobenzenesulfonic acid; inflammatory bowel disease; experimental colitis;

D O I：

10.1152/ajpgi.1997.272.1.G84

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Because exacerbation of colitis seems to be associated with stress, we proposed evaluating the influence of stress and the involvement of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) on experimental colitis in rats. Partial restraint stress was applied during 4 consecutive days, before or after intracolonic 2,4,6-trinitrobenzenesulfonic acid (TNB) instillation (15 mg) in rats. Finally, two groups of rats were centrally injected with alpha-helical CRF-(9-41) (5 mu g) or AVP antagonist (5 mu g) before each session of stress. Stress was applied before or right after TNB enhanced colitis, with an increase in macroscopic and histological scores and myeloperoxidase activity. alpha-Helical CRF-(9-41) or AVP antagonist had no effect on TNB-induced colitis but enhanced the effects of stress on colitis. These results show that stress may exacerbate experimental colitis in rats and that CRF and AVP are not responsible for this effect.

引用

页码：G84 / G91

页数：8

共 32 条

[31] CORTICOTROPIN-RELEASING FACTOR DIRECTLY MEDIATES COLONIC RESPONSES TO STRESS [J].