Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: A clinical trial assessing compliance, efficacy, and safety

被引：419

作者：

Rubin, C ^{[1
]}

Recker, R

Cullen, D

Ryaby, J

McCabe, J

McLeod, K

机构：

[1] SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY 11794 USA

[2] Creighton Univ, Osteoporosis Res Ctr, Omaha, NE USA

[3] Juveat Inc, Clin Res, Somerset, NJ USA

[4] SUNY Binghamton, Dept Bioengn, Binghamton, NY USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 03期

关键词：

osteoporosis; anabolic; mechanical loading; vibration; low-level; frequency; osteogenic; muscle; skeleton; aging; menopause; bone; antiresorptive;

D O I：

10.1359/JBMR.0301251

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 1-year prospective, randomized, double-blind, and placebo-controlled trial of 70 postmenopausal women demonstrated that brief periods (<20 minutes) of a low-level (0.2g, 30 Hz) vibration applied during quiet standing can effectively inhibit bone loss in the spine and femur, with efficacy increasing significantly with greater compliance, particularly in those subjects with lower body mass.

引用

页码：343 / 351

页数：9

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