Optical readout of gold nanoparticle-based DNA microarrays without silver enhancement

被引：45

作者：

Blab, GA

Cognet, L

Berciaud, S

Alexandre, I

Husar, D

Remacle, J

Lounis, B ^{[1
]}

机构：

[1] CNRS, Ctr Phys Mol Opt & Hertzienne, UMR 5798, F-33405 Talence, France

[2] Univ Bordeaux 1, F-33405 Talence, France

[3] Eppendorf Array Technol, B-5000 Namur, Belgium

来源：

BIOPHYSICAL JOURNAL | 2006年 / 90卷 / 01期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1529/biophysj.105.076182

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We present a novel readout scheme for gold nanoparticle- based DNA microarrays relying on ''Laser-Induced Scattering around a NanoAbsorber''. It provides direct counting of individual nanoparticles present on each array spot and stable signals, without any silver enhancement. Given the detection of nanometer-sized particles, which minimize the steric hindrance, the linear dynamic range of the method is particularly large and well suited for microarray detection.

引用

收藏

页码：L13 / L15

页数：3

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