Semiconductor quantum dots and metal nanoparticles: syntheses, optical properties, and biological applications

被引：426

作者：

Biju, Vasudevanpillai ^{[1
,2
]}

Itoh, Tamitake ^{[1
]}

Anas, Abdulaziz ^{[1
]}

Sujith, Athiyanathil ^{[1
]}

Ishikawa, Mitsuru ^{[1
,2
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Hlth Technol Res Ctr, Nano Bioanal Team, Takamatsu, Kagawa 7610395, Japan

[2] Univ Kerala, Ctr Arthropod Bioresources & Biotechnol, Trivandrum 695001, Kerala, India

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2008年 / 391卷 / 07期

关键词：

quantum dots; CdSe; CdSe-ZnS; photoluminescence; blinking; nanoparticles; Au; Ag; plasmon; SERS; in vitro imaging; in vivo imaging;

D O I：

10.1007/s00216-008-2185-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We review the syntheses, optical properties, and biological applications of cadmium selenide (CdSe) and cadmium selenide-zinc sulfide (CdSe-ZnS) quantum dots (QDs) and gold (Au) and silver (Ag) nanoparticles (NPs). Specifically, we selected the syntheses of QDs and Au and Ag NPs in aqueous and organic phases, size- and shape-dependent photoluminescence (PL) of QDs and plasmon of metal NPs, and their bioimaging applications. The PL properties of QDs are discussed with reference to their band gap structure and various electronic transitions, relations of PL and photoactivated PL with surface defects, and blinking of single QDs. Optical properties of Ag and Au NPs are discussed with reference to their size- and shape-dependent surface plasmon bands, electron dynamics and relaxation, and surface-enhanced Raman scattering (SERS). The bioimaging applications are discussed with reference to in vitro and in vivo imaging of live cells, and in vivo imaging of cancers, tumor vasculature, and lymph nodes. Other aspects of the review are in vivo deep tissue imaging, multiphoton excitation, NIR fluorescence and SERS imaging, and toxic effects of NPs and their clearance from the body.

引用

页码：2469 / 2495

页数：27

共 291 条

[1] Biomedical applications of electrostatic layer-by-layer nano-assembly of polymers, enzymes, and nanoparticles [J].

Ai, H ;

Jones, SA ;

Lvov, YM .

CELL BIOCHEMISTRY AND BIOPHYSICS, 2003, 39 (01) :23-43

[2] Nanocrystal targeting in vivo [J].

Åkerman, ME ;

Chan, WCW ;

Laakkonen, P ;

Bhatia, SN ;

Ruoslahti, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12617-12621

[3] ANOMALOUSLY INTENSE RAMAN-SPECTRA OF PYRIDINE AT A SILVER ELECTRODE [J].

ALBRECHT, MG ;

CREIGHTON, JA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (15) :5215-5217

[4] Quantum dots as cellular probes [J].

Alivisatos, AP ;

Gu, WW ;

Larabell, C .

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2005, 7 :55-76

[5] Perspectives on the physical chemistry of semiconductor nanocrystals [J].

Alivisatos, AP .

JOURNAL OF PHYSICAL CHEMISTRY, 1996, 100 (31) :13226-13239

[6] Semiconductor clusters, nanocrystals, and quantum dots [J].

Alivisatos, AP .

SCIENCE, 1996, 271 (5251) :933-937

[7] Optical absorption spectra of nanocrystal gold molecules [J].

Alvarez, MM ;

Khoury, JT ;

Schaaff, TG ;

Shafigullin, MN ;

Vezmar, I ;

Whetten, RL .

JOURNAL OF PHYSICAL CHEMISTRY B, 1997, 101 (19) :3706-3712

[8] Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response [J].

Anikeeva, Nadia ;

Lebedeva, Tatiana ;

Clapp, Aaron R. ;

Goldman, Ellen R. ;

Dustin, Michael L. ;

Mattoussi, Hedi ;

Sykulev, Yuri .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :16846-16851

[9]

[Anonymous], 2011, RECENT PAT BIOTECHNO

[10] Surface state analysis of photobrightening in CdSe nanocrystal thin films [J].

Asami, H ;

Abe, Y ;

Ohtsu, T ;

Kamiya, I ;

Hara, M .

JOURNAL OF PHYSICAL CHEMISTRY B, 2003, 107 (46) :12566-12568

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