Recent advances in brain cholesterol dynamics: Transport, domains, and Alzheimer's disease

被引：103

作者：

Wood, WG

Schroeder, F

Avdulov, NA

Chochina, SV

Igbavboa, U

机构：

[1] Vet Adm Med Ctr, GRECC, Minneapolis, MN 55417 USA

[2] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55417 USA

[3] Texas A&M Univ, Texas Vet Med Ctr, Dept Physiol & Pharmacol, College Stn, TX 77843 USA

来源：

LIPIDS | 1999年 / 34卷 / 03期

关键词：

D O I：

10.1007/s11745-999-0357-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Major advances in understanding cholesterol dynamics and the role that cholesterol plays in vascular disease have recently been made. The brain is an organ that is highly enriched in cholesterol, but progress toward understanding brain cholesterol dynamics has been relatively limited. This review examines recent contributions to the understanding of brain cholesterol dynamics, focusing on extracellular and intracellular lipid carrier proteins, membrane cholesterol domains, and emerging evidence linking an association between cholesterol dynamics and Alzheimer's disease.

引用

页码：225 / 234

页数：10

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