MN blood groups and bipolar disorder: Evidence of genotypic association and Hardy-Weinberg disequilibrium

被引:18
作者
Alda, M [1 ]
Grof, P [1 ]
Grof, E [1 ]
机构
[1] Univ Ottawa, Dept Psychiat, Ottawa, ON K1N 6N5, Canada
关键词
bipolar disorder; association; lithium; MN blood groups; Hardy-Weinberg equilibrium;
D O I
10.1016/S0006-3223(98)00013-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: MN blood groups have been studied in the past as a genetic marker of bipolar disorder (BD). Several previous studies reported art association of the illness with lower frequency of blood group NN, Methods: We analyzed distribution of MN blood groups in a sample of 174 patients with ED, 176 with unipolar depression, 98 with schizophrenia, and 331 healthy controls. In addition, we tested whether the inferred genotypes conform to Hardy-Weinberg equilibrium (HWE), Results: The frequency of NN phenotype was significantly lower among the bipolar patients than in any of the other three groups (p < .001), The genotype frequencies in the ED group deviated significantly from those expected under HWE (p < .01), Conclusions: These results suggest a possible locus on chromosome 4 (4q28-q31.1) associated with generic susceptibility to bipolar illness. (C) 1998 Society of Biological Psychiatry.
引用
收藏
页码:361 / 363
页数:3
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