MN blood groups and bipolar disorder: Evidence of genotypic association and Hardy-Weinberg disequilibrium

被引：18

作者：

Alda, M ^{[1
]}

Grof, P ^{[1
]}

Grof, E ^{[1
]}

机构：

[1] Univ Ottawa, Dept Psychiat, Ottawa, ON K1N 6N5, Canada

来源：

BIOLOGICAL PSYCHIATRY | 1998年 / 44卷 / 05期

关键词：

bipolar disorder; association; lithium; MN blood groups; Hardy-Weinberg equilibrium;

D O I：

10.1016/S0006-3223(98)00013-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: MN blood groups have been studied in the past as a genetic marker of bipolar disorder (BD). Several previous studies reported art association of the illness with lower frequency of blood group NN, Methods: We analyzed distribution of MN blood groups in a sample of 174 patients with ED, 176 with unipolar depression, 98 with schizophrenia, and 331 healthy controls. In addition, we tested whether the inferred genotypes conform to Hardy-Weinberg equilibrium (HWE), Results: The frequency of NN phenotype was significantly lower among the bipolar patients than in any of the other three groups (p < .001), The genotype frequencies in the ED group deviated significantly from those expected under HWE (p < .01), Conclusions: These results suggest a possible locus on chromosome 4 (4q28-q31.1) associated with generic susceptibility to bipolar illness. (C) 1998 Society of Biological Psychiatry.

引用

页码：361 / 363

页数：3

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