The versatility of Shigella effectors

被引：116

作者：

Ogawa, Michinaga ^{[1
]}

Honda, Yutaka ^{[1
]}

Ashida, Hiroshi ^{[1
]}

Suzuki, Masato ^{[1
]}

Sasakawa, Chihiro ^{[1
,2
,3
]}

机构：

[1] Univ Tokyo, Dept Microbiol & Immunol, Inst Med Sci, Minato Ku, Tokyo 1088639, Japan

[2] Univ Tokyo, Dept Infect Dis Control, Inst Med Sci, Int Res Ctr Infect Dis,Minato Ku, Tokyo 1088639, Japan

[3] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan

来源：

NATURE REVIEWS MICROBIOLOGY | 2008年 / 6卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1038/nrmicro1814

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

When Shigella infect the intestinal epithelium, they deliver several effectors through the type III secretion system (T3SS) into the surrounding space and directly into the host-cell. cytoplasm, where they can mimic and usurp host cellular functions or subvert host-cell signalling pathways and the immune response. Although bacterial strategies and mechanisms of infection vary greatly, recent studies of Shigella effectors have revealed that Shigella possess a highly evolved strategy for infection.

引用

页码：11 / 16

页数：6

共 40 条

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