Effects of homocysteine on the binding of extracellular-superoxide dismutase to the endothelial cell surface

被引:96
作者
Yamamoto, M [1 ]
Hara, H [1 ]
Adachi, T [1 ]
机构
[1] Gifu Pharmaceut Univ, Lab Clin Pharmaceut, Gifu 5028585, Japan
关键词
homocysteine; extracellular-superoxide dismutase; endothelial cell; heparan sulfate proteoglycan; atherosclerosis;
D O I
10.1016/S0014-5793(00)02260-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Homocysteine is known to be a risk factor for several vascular diseases. Previously, we found a significant association between plasma homocysteine and plasma extracellular-superoxide dismutase (EC-SOD) levels. The binding of EC-SOD to human and bovine aortic endothelial cell cultures showed significant decreases after incubation with 10 muM homocysteine, whereas the expression of EC-SOD in fibroblast cell cultures was inhibited with a high concentration (1 mM) of homocysteine. Furthermore, binding of EC-SOD to heparin immobilized on plates was decreased with homocysteine. These observations suggested that homocysteine decreases the binding of EC-SOD to vascular endothelial cell surfaces by degradation of endothelial heparan sulfate proteoglycan, which results in a loss of the ability to protect endothelial cell surfaces from oxidative stress. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:159 / 162
页数:4
相关论文
共 39 条
[1]   NONENZYMATIC GLYCATION OF HUMAN EXTRACELLULAR SUPEROXIDE-DISMUTASE [J].
ADACHI, T ;
OHTA, H ;
HIRANO, K ;
HAYASHI, K ;
MARKLUND, SL .
BIOCHEMICAL JOURNAL, 1991, 279 :263-267
[2]   Substitution of glycine for arginino-213 in extracellular-superoxide dismutase impairs affinity for heparin and endothelial cell surface [J].
Adachi, T ;
Yamada, H ;
Yamada, Y ;
Morihara, N ;
Yamazaki, N ;
Murakami, T ;
Futenma, A ;
Kato, K ;
Hirano, K .
BIOCHEMICAL JOURNAL, 1996, 313 :235-239
[3]   QUANTITATIVE-ANALYSIS OF EXTRACELLULAR-SUPEROXIDE DISMUTASE IN SERUM AND URINE BY ELISA WITH MONOCLONAL-ANTIBODY [J].
ADACHI, T ;
OHTA, H ;
YAMADA, H ;
FUTENMA, A ;
KATO, K ;
HIRANO, K .
CLINICA CHIMICA ACTA, 1992, 212 (03) :89-102
[4]   HEPARIN-INDUCED RELEASE OF EXTRACELLULAR-SUPEROXIDE DISMUTASE FORM(V) TO PLASMA [J].
ADACHI, T ;
YAMADA, H ;
FUTENMA, A ;
KATO, K ;
HIRANO, K .
JOURNAL OF BIOCHEMISTRY, 1995, 117 (03) :586-590
[5]   QUANTITATIVE AND QUALITATIVE CHANGES OF EXTRACELLULAR-SUPEROXIDE DISMUTASE IN PATIENTS WITH VARIOUS DISEASES [J].
ADACHI, T ;
NAKAMURA, M ;
YAMADA, H ;
FUTENMA, A ;
KATO, K ;
HIRANO, K .
CLINICA CHIMICA ACTA, 1994, 229 (1-2) :123-131
[6]   Homocysteine-dependent alterations in mitochondrial gene expression, function and structure -: Homocysteine and H2O2 act synergistically to enhance mitochondrial damage [J].
Austin, RC ;
Sood, SK ;
Dorward, AM ;
Singh, G ;
Shaughnessy, SG ;
Pamidi, S ;
Outinen, PA ;
Weitz, JI .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (46) :30808-30817
[7]   ARTERIAL ENDOTHELIAL BARRIER DYSFUNCTION - ACTIONS OF HOMOCYSTEINE AND THE HYPOXANTHINE-XANTHINE OXIDASE FREE-RADICAL GENERATING-SYSTEM [J].
BERMAN, RS ;
MARTIN, W .
BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 (04) :920-926
[8]   Homocysteine mediated endothelial cell toxicity and its amelioration [J].
Blundell, G ;
Jones, BG ;
Rose, FA ;
Tudball, N .
ATHEROSCLEROSIS, 1996, 122 (02) :163-172
[9]   HETEROZYGOSITY FOR HOMOCYSTINURIA IN PREMATURE PERIPHERAL AND CEREBRAL OCCLUSIVE ARTERIAL-DISEASE [J].
BOERS, GHJ ;
SMALS, AGH ;
TRIJBELS, FJM ;
FOWLER, B ;
BAKKEREN, JAJM ;
SCHOONDERWALDT, HC ;
KLEIJER, WJ ;
KLOPPENBORG, PWC .
NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (12) :709-715
[10]   HYPERHOMOCYSTEINEMIA - AN INDEPENDENT RISK FACTOR FOR VASCULAR-DISEASE [J].
CLARKE, R ;
DALY, L ;
ROBINSON, K ;
NAUGHTEN, E ;
CAHALANE, S ;
FOWLER, B ;
GRAHAM, I .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (17) :1149-1155