Cancer, cadmium and genome integrity

被引：148

作者：

McMurray, CT

Tainer, JA

机构：

[1] Mayo Clin & Mayo Fdn, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[4] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

来源：

NATURE GENETICS | 2003年 / 34卷 / 03期

关键词：

D O I：

10.1038/ng0703-239

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The direct inhibition of DNA mismatch repair by cadmium provides a molecular mechanism for cadmium toxicity with profound implications for human health, risk assessment and biological understanding of environmental mutagens. Alteration of key DNA damage response pathways may prove even more important than direct DNA damage by mutagens.

引用

页码：239 / 241

页数：3

共 15 条

[1] MDB: The metalloprotein database and browser at the scripps research institute
Castagnetto, JM
Hennessy, SW
Roberts, VA
Getzoff, ED
Tainer, JA
Pique, ME
[J]. NUCLEIC ACIDS RESEARCH, 2002, 30 (01) : 379 - 382
[2] DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers
Drotschmann, K
Hall, MC
Shcherbakova, PV
Wang, H
Erie, DA
Brownewell, FR
Kool, ET
Kunkel, TA
[J]. BIOLOGICAL CHEMISTRY, 2002, 383 (06) : 969 - 975
[3] DNA damage and repair
Friedberg, EC
[J]. NATURE, 2003, 421 (6921) : 436 - 440
[4] The carcinogenicity of metals in humans
Hayes, RB
[J]. CANCER CAUSES & CONTROL, 1997, 8 (03) : 371 - 385
[5] Occupational exposure to heavy metals:: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected
Hengstler, JG
Bolm-Audorff, U
Faldum, A
Janssen, K
Reifenrath, M
Götte, W
Jung, DL
Mayer-Popken, O
Fuchs, J
Gebhard, S
Bienfait, HG
Schlink, K
Dietrich, C
Faust, D
Epe, B
Oesch, F
[J]. CARCINOGENESIS, 2003, 24 (01) : 63 - 73
[6] Genome maintenance mechanisms for preventing cancer
Hoeijmakers, JHJ
[J]. NATURE, 2001, 411 (6835) : 366 - 374
[7] Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures
Hopfner, KP
Tainer, JA
[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 2003, 13 (02) : 249 - 255
[8] The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair
Hopfner, KP
Craig, L
Moncalian, G
Zinkel, RA
Usui, T
Owen, BAL
Karcher, A
Henderson, B
Bodmer, JL
McMurray, CT
Carney, JP
Petrini, JHJ
Tainer, JA
[J]. NATURE, 2002, 418 (6897) : 562 - 566
[9] Cadmium is a mutagen that acts by inhibiting mismatch repair
Jin, YH
Clark, AB
Slebos, RJC
Al-Refai, H
Taylor, JA
Kunkel, TA
Resnick, MA
Gordenin, DA
[J]. NATURE GENETICS, 2003, 34 (03) : 326 - 329
[10] Maintenance of genome stability in Saccharomyces cerevisiae
Kolodner, RD
Putnam, CD
Myung, K
[J]. SCIENCE, 2002, 297 (5581) : 552 - 557

← 1 2 →