Cancer, cadmium and genome integrity

被引：148

作者：

McMurray, CT

Tainer, JA

机构：

[1] Mayo Clin & Mayo Fdn, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[4] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

来源：

NATURE GENETICS | 2003年 / 34卷 / 03期

关键词：

D O I：

10.1038/ng0703-239

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The direct inhibition of DNA mismatch repair by cadmium provides a molecular mechanism for cadmium toxicity with profound implications for human health, risk assessment and biological understanding of environmental mutagens. Alteration of key DNA damage response pathways may prove even more important than direct DNA damage by mutagens.

引用

页码：239 / 241

页数：3

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