Overactive action monitoring in obsessive-compulsive disorder: Evidence from functional magnetic resonance imaging

被引:259
作者
Ursu, S
Stenger, VA
Shear, MK
Jones, MR
Carter, CS
机构
[1] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA
[2] Univ Pittsburgh, Ctr Neural Basis Cognit, Pittsburgh, PA 15260 USA
[3] Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA
[4] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA
[5] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1111/1467-9280.24411
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
The anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been found to be hyperactive at rest, during symptom provocation, and after commission of errors in cognitive tasks. This hyperactivity might reflect an abnormality in conflict detection, a hypothesized basic mechanism for the action-monitoring Junction of the ACC. This hypothesis was tested using functional magnetic resonance imaging, by scanning 11 OCD patients and 13 matched control subjects while they performed a version of the continuous-performance task with four trial types that induced graded levels of response conflict. Although a behavioral index of conflict (i.e., accuracy) was similar for patients and control subjects, the ACC activation was increased in patients during high-conflict trials. The error-related activity in the same brain region was also higher in patients, consistent with previous electrophysiological findings. Both conflict- and error-related activin; showed trends for positive correlations with severity of OCD symptoms, but not with anxiety. These findings suggest that as part of an overactive action-monitoring system, the ACC is more directly involved in the pathophysiology of OCD than previously thought.
引用
收藏
页码:347 / 353
页数:7
相关论文
共 34 条
[31]  
SWEDO SE, 1992, ARCH GEN PSYCHIAT, V49, P690
[32]   The timing of action-monitoring processes in the anterior cingulate cortex [J].
van Veen, V ;
Carter, CS .
JOURNAL OF COGNITIVE NEUROSCIENCE, 2002, 14 (04) :593-602
[33]   Anterior cingulate cortex, conflict monitoring, and levels of processing [J].
van Veen, V ;
Cohen, JD ;
Botvinick, MM ;
Stenger, VA ;
Carter, CS .
NEUROIMAGE, 2001, 14 (06) :1302-1308
[34]   RAPID AUTOMATED ALGORITHM FOR ALIGNING AND RESLICING PET IMAGES [J].
WOODS, RP ;
CHERRY, SR ;
MAZZIOTTA, JC .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1992, 16 (04) :620-633