Peroxisome proliferator-activated receptors - from active regulators of macrophage biology to pharmacological targets in the treatment of cardiovascular disease

被引：39

作者：

Bouhlel, M. A. ^{[1
,2
]}

Staels, B. ^{[1
,2
]}

Chinetti-Gbaguidi, G. ^{[1
,2
]}

机构：

[1] Inst Pasteur, INSERM, Dept Atherosclerose, U545, Lille, France

[2] Univ Lille 2, Fac Med, Fac Sci Pharmaceut & Biol, Lille, France

来源：

JOURNAL OF INTERNAL MEDICINE | 2008年 / 263卷 / 01期

关键词：

cardiovascular disease; gene regulation; macrophages; peroxisome proliferator-activated receptor;

D O I：

10.1111/j.1365-2796.2007.01892.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Altered macrophage functions contribute to the pathogenesis of many infectious, immunological and inflammatory disease processes. Pharmacological modulation of macrophage activities therefore represents an important strategy for the prevention and treatment of inflammation-related diseases, such as atherosclerosis. This review focuses on recent advances on the role of the peroxisome proliferator-activated receptor transcription factor family in the modulation of lipid homeostasis and the inflammatory response in macrophages and the potential participation of these actions in the modulation of metabolic and cardiovascular disease.

引用

页码：28 / 42

页数：15

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