Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase

被引：7

作者：

Bakhanashvili, M ^{[1
]}

Novitsky, E

Rubinstein, E

Levy, I

Rahav, G

机构：

[1] Chaim Sheba Med Ctr, Infect Dis Unit, IL-52621 Tel Hashomer, Israel

[2] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 04期

关键词：

D O I：

10.1128/AAC.49.4.1576-1579.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the ability of p53 in cytoplasm to excise nucleoside analogs (NAs). A decrease in incorporation of NAs by human immunodeficiency virus type 1 reverse transcriptase and their excision from DNA by p53, provided by the cytoplasmic fraction of LCC2 cells, suggest that p53 in cytoplasm may act as an external proofreader for NA incorporation.

引用

页码：1576 / 1579

页数：4

共 27 条

[11]

Feng L, 2000, INT J MOL MED, V5, P597

[12] p53-associated 3′→5′ exonuclease activity in nuclear and cytoplasmic compartments of cells [J].

Gila, L ;

Elena, N ;

Yechezkel, S ;

Mary, B .

ONCOGENE, 2003, 22 (02) :233-245

[13] Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein [J].

Huang, P .

ONCOGENE, 1998, 17 (03) :261-270

[14]

JI J, 1992, BIOCHEMISTRY-US, V30, P7566

[15] Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase α-primase [J].

Melle, C ;

Nasheuer, HP .

NUCLEIC ACIDS RESEARCH, 2002, 30 (07) :1493-1499

[16] Molecular basis of fidelity of DNA synthesis and nucleotide specificity of retroviral reverse transcriptases [J].

Menéndez-Arias, L .

PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 71, 2002, 71 :91-147

[17] A mechanism of AZT resistance: An increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase [J].

Meyer, PR ;

Matsuura, SE ;

Mian, AM ;

So, AG ;

Scott, WA .

MOLECULAR CELL, 1999, 4 (01) :35-43

[18] p53 protein exhibits 3'-to-5' exonuclease activity [J].

Mummenbrauer, T ;

Janus, F ;

Muller, B ;

Wiesmuller, L ;

Deppert, W ;

Grosse, F .

CELL, 1996, 85 (07) :1089-1099

[19] EXTENSION OF MISMATCHED 3' TERMINI OF DNA IS A MAJOR DETERMINANT OF THE INFIDELITY OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 REVERSE-TRANSCRIPTASE [J].

PERRINO, FW ;

PRESTON, BD ;

SANDELL, LL ;

LOEB, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (21) :8343-8347

[20]

RAGIMOV N, 1993, ONCOGENE, V8, P1183

← 1 2 3 →