Linezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococci

被引：91

作者：

Kutscha-Lissberg, F ^{[1
]}

Hebler, U ^{[1
]}

Muhr, G ^{[1
]}

Köller, M ^{[1
]}

机构：

[1] Ruhr Univ Bochum, BG Kliniken Bergmannsheil Univ Klin, Chirurg Klin, Dept Surg,Trauma Ctr, D-44789 Bochum, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 12期

关键词：

D O I：

10.1128/AAC.47.12.3964-3966.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of 35 to 124 min after administration of the preoperative dose, except in bone specimens, where they reached 3.9 +/- 2.0 mg/liter.

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页码：3964 / 3966

页数：3

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