GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements

被引:205
作者
Tremblay, JJ
Viger, RS
机构
[1] CHU Laval, Res Ctr, Ontogeny & Reprod Res Unit, Quebec City, PQ G1V 4G2, Canada
[2] Univ Laval, Dept Obstet & Gynecol, Ctr Res Biol Reprod, Quebec City, PQ G1V 4G2, Canada
关键词
D O I
10.1210/en.142.3.977
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The GATA factors are a group of transcriptional regulators that play essential roles in cell differentiation, organ morphogenesis, and tissue-specific gene expression during development. The six vertebrate GATA factors are expressed in a broad spectrum of tissues, including the hemopoietic system, heart, gut, brain, placenta, pituitary, and gonads. Interestingly, GATA-like DNA-binding proteins are found in the gonads of several species, ranging from lower invertebrates to humans, thus supporting an evolutionary conserved and crucial role for these factors in gonadal development and function. Indeed, GATA factors are expressed from the onset of gonadal development and are later found in multiple cell lineages of both the testis and ovary. We now report that GATA-4 differentially activates transcription of several genes expressed in the gonads that encode either steroidogenic enzymes (steroidogenic acute regulatory protein and aromatase), hormones (inhibin cu and Mullerian inhibiting substance) and a transcription factor (SF-1) known to be essential for gonadal development and function. Thus, our results identify GATA-4 as an important regulator of gonadal gene transcription where its specificity of action is mediated through synergistic interactions with other transcription factors such as SF-1.
引用
收藏
页码:977 / 986
页数:10
相关论文
共 72 条
[21]   Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: Potential links in endocrine development [J].
Ikeda, Y ;
Swain, A ;
Weber, TJ ;
Hentges, KE ;
Zanaria, E ;
Lalli, E ;
Tamai, KT ;
SassoneCorsi, P ;
LovellBadge, R ;
Camerino, G ;
Parker, KL .
MOLECULAR ENDOCRINOLOGY, 1996, 10 (10) :1261-1272
[22]   THE NUCLEAR RECEPTOR STEROIDOGENIC FACTOR-1 ACTS AT MULTIPLE LEVELS OF THE REPRODUCTIVE AXIS [J].
INGRAHAM, HA ;
LALA, DS ;
IKEDA, Y ;
LUO, XR ;
SHEN, WH ;
NACHTIGAL, MW ;
ABBUD, R ;
NILSON, JH ;
PARKER, KL .
GENES & DEVELOPMENT, 1994, 8 (19) :2302-2312
[23]   ERYTHROID TRANSCRIPTION FACTOR GATA-1 IS ABUNDANTLY TRANSCRIBED IN MOUSE TESTIS [J].
ITO, E ;
TOKI, T ;
ISHIHARA, H ;
OHTANI, H ;
GU, L ;
YOKOYAMA, M ;
ENGEL, JD ;
YAMAMOTO, M .
NATURE, 1993, 362 (6419) :466-468
[24]   Synergistic activation of the inhibin α-promoter by steroidogenic factor-1 and cyclic adenosine 3′,5′-monophosphate [J].
Ito, M ;
Park, Y ;
Weck, J ;
Mayo, KE ;
Jameson, JL .
MOLECULAR ENDOCRINOLOGY, 2000, 14 (01) :66-81
[25]   Expression and regulation of transcription factors GATA-4 and GATA-6 in developing mouse testis [J].
Ketola, I ;
Rahman, N ;
Toppari, J ;
Bielinska, M ;
Porter-Tinge, SB ;
Tapanainen, JS ;
Huhtaniemi, IT ;
Wilson, DB ;
Heikinheimo, M .
ENDOCRINOLOGY, 1999, 140 (03) :1470-1480
[26]   Reciprocal changes in the expression of transcription factors GATA-4 and GATA-6 accompany adrenocortical tumorigenesis in mice and humans [J].
Kiiveri, S ;
Siltanen, S ;
Rahman, N ;
Bielinska, M ;
Lehto, VP ;
Huhtaniemi, IT ;
Muglia, LJ ;
Wilson, DB ;
Heikinheimo, M .
MOLECULAR MEDICINE, 1999, 5 (07) :490-501
[27]   DNA-BINDING SPECIFICITIES OF THE GATA TRANSCRIPTION FACTOR FAMILY [J].
KO, LJ ;
ENGEL, JD .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (07) :4011-4022
[28]  
Koutsourakis M, 1999, DEVELOPMENT, V126, P723
[29]   GATA4 transcription factor is required for ventral morphogenesis and heart tube formation [J].
Kuo, CT ;
Morrisey, EE ;
Anandappa, R ;
Sigrist, K ;
Lu, MM ;
Parmacek, MS ;
Soudais, C ;
Leiden, JM .
GENES & DEVELOPMENT, 1997, 11 (08) :1048-1060
[30]   Transcription factors GATA-4 and GATA-6 and a GATA family cofactor, FOG-2, are expressed in human ovary and sex cord-derived ovarian tumors [J].
Laitinen, MPE ;
Anttonen, M ;
Ketola, I ;
Wilson, DB ;
Ritvos, O ;
Butzow, R ;
Heikinheimo, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (09) :3476-3483