Stereoselective construction of a quaternary carbon substituted with multifunctional groups: application to the concise synthesis of (+)-ethosuximide

被引：32

作者：

Abe, T

Suzuki, T

Sekiguchi, K

Hosokawa, S

Kobayashi, S ^{[1
]}

机构：

[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Noda, Chiba 2788510, Japan

[2] Tokyo Univ Sci, Frontier Res Ctr Genom Drug Discovery, Noda, Chiba 2788510, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 52期

关键词：

D O I：

10.1016/j.tetlet.2003.10.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetically useful beta,gamma-unsaturated carbonyl compounds having a quaternary carbon at the alpha-position were prepared with high stereoselectivity by the reaction of a dienolate anion derived from alpha,beta-unsaturated imide having a chiral auxiliary and electrophiles (ethyl acetate and allyl iodide as the C-2 and C-3 unit, respectively). This method was applied to a short asymmetric synthesis of (+)-ethosuximide. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：9303 / 9305

页数：3

共 15 条

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