β1 integrins and neural stem cells:: making sense of the extracellular environment

被引：87

作者：

Campos, LS ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge, England

来源：

BIOESSAYS | 2005年 / 27卷 / 07期

关键词：

D O I：

10.1002/bies.20256

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neural Stem Cells (NSC) are present in the developing and adult CNS. In both the embryonic and adult neurogenic regions, beta 1 integrins may act as sensors for the changing extracellular matrix. Here we highlight the integrative functions that beta 1 integrins may play in the "niche" by regulating NSC growth factor responsiveness in a timely and spatially controlled manner. beta 1 integrins may provide NSC with the capacity to react to a dynamic "niche", and to respond adequately by either remaining as stem cells or by differentiating and migrating away to shape the developing cortex. (c) 2005 Wiley Periodicals, Inc.

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页码：698 / 707

页数：10

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