β1 integrins and neural stem cells:: making sense of the extracellular environment

被引：87

作者：

Campos, LS ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge, England

来源：

BIOESSAYS | 2005年 / 27卷 / 07期

关键词：

D O I：

10.1002/bies.20256

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neural Stem Cells (NSC) are present in the developing and adult CNS. In both the embryonic and adult neurogenic regions, beta 1 integrins may act as sensors for the changing extracellular matrix. Here we highlight the integrative functions that beta 1 integrins may play in the "niche" by regulating NSC growth factor responsiveness in a timely and spatially controlled manner. beta 1 integrins may provide NSC with the capacity to react to a dynamic "niche", and to respond adequately by either remaining as stem cells or by differentiating and migrating away to shape the developing cortex. (c) 2005 Wiley Periodicals, Inc.

引用

收藏

页码：698 / 707

页数：10

相关论文

共 101 条

[21] The glial identity of neural stem cells [J].

Doetsch, F .

NATURE NEUROSCIENCE, 2003, 6 (11) :1127-1134

[22] Subventricular zone astrocytes are neural stem cells in the adult mammalian brain [J].

Doetsch, F ;

Caillé, I ;

Lim, DA ;

García-Verdugo, JM ;

Alvarez-Buylla, A .

CELL, 1999, 97 (06) :703-716

[23] A niche for adult neural stem cells [J].

Doetsch, F .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2003, 13 (05) :543-550

[24] LAMININ THROUGH ITS LONG ARM E8 FRAGMENT PROMOTES THE PROLIFERATION AND DIFFERENTIATION OF MURINE NEUROEPITHELIAL CELLS-INVITRO [J].

DRAGO, J ;

NURCOMBE, V ;

BARTLETT, PF .

EXPERIMENTAL CELL RESEARCH, 1991, 192 (01) :256-265

[25] BASIC FIBROBLAST GROWTH-FACTOR UP-REGULATES STEADY-STATE LEVELS OF LAMININ-B1 AND LAMININ-B2 CHAIN MESSENGER-RNA IN CULTURED NEUROEPITHELIAL CELLS [J].

DRAGO, J ;

NURCOMBE, V ;

PEARSE, MJ ;

MURPHY, M ;

BARTLETT, PF .

EXPERIMENTAL CELL RESEARCH, 1991, 196 (02) :246-254

[26] CONSEQUENCES OF LACK OF BETA-1 INTEGRIN GENE-EXPRESSION IN MICE [J].

FASSLER, R ;

MEYER, M .

GENES & DEVELOPMENT, 1995, 9 (15) :1896-1908

[27] Interactions between fibroblast growth factors and Notch regulate neuronal differentiation [J].

Faux, CH ;

Turnley, AM ;

Epa, R ;

Cappai, R ;

Bartlett, PF .

JOURNAL OF NEUROSCIENCE, 2001, 21 (15) :5587-5596

[28] Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development [J].

Ford-Perriss, M ;

Turner, K ;

Guimond, S ;

Apedaile, A ;

Haubeck, HD ;

Turnbull, J ;

Murphy, M .

DEVELOPMENTAL DYNAMICS, 2003, 227 (02) :170-184

[29] Reelin, Disabled 1, and β1 integrins are required for the formation of the radial glial scaffold in the hippocampus [J].

Förster, E ;

Tielsch, A ;

Saum, B ;

Weiss, KH ;

Johanssen, C ;

Graus-Porta, D ;

Müller, U ;

Frotscher, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :13178-13183

[30] Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C [J].

Garcion, E ;

Halilagic, A ;

Faissner, A ;

ffrench-Constant, C .

DEVELOPMENT, 2004, 131 (14) :3423-3432

← 1 2 3 4 5 6 7 8 9 10 →