Hypoxia Induced NF-κB

被引：130

作者：

D'Ignazio, Laura ^{[1
]}

Rocha, Sonia ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, Ctr Gene Regulat & Express, Dow St, Dundee DD1 5EH, Scotland

来源：

CELLS | 2016年 / 5卷 / 01期

基金：

英国惠康基金;

关键词：

Hypoxia; NF-kappa B; IKK; HIF-1; PHDs; FIH; TAK; ubiquitin; TUMOR-SUPPRESSOR CYLD; SUMO-1; MODIFICATION; GENE-EXPRESSION; ALPHA; ACTIVATION; PATHWAY; COMPLEX; HYDROXYLATION; REGULATORS; MECHANISM;

D O I：

10.3390/cells5010010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

As Nuclear Factor-kappa B (NF-kappa B) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-kappa B becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-kappa B. In addition, we will discuss the role of NF-kappa B in the control of the cellular response to hypoxia.

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页数：8

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