Dissociable effects of monoamine reuptake inhibitors on distinct forms of impulsive behavior in rats

被引:136
作者
Baarendse, Petra J. J. [2 ]
Vanderschuren, Louk J. M. J. [1 ,2 ]
机构
[1] Univ Utrecht, Fac Vet Med, Div Behav Neurosci, Dept Anim Sci & Soc, Utrecht, Netherlands
[2] UMC Utrecht, Dept Neurosci & Pharmacol, Rudolf Magnus Inst Neurosci, NL-3584 CG Utrecht, Netherlands
关键词
Impulsivity; Delayed reward; Five-choice serial reaction time task; Dopamine; Serotonin; Noradrenaline; REACTION-TIME-TASK; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; TERM ATOMOXETINE TREATMENT; NUCLEUS-ACCUMBENS CORE; D-AMPHETAMINE; PREFRONTAL CORTEX; RESPONSE-INHIBITION; 5-HT DEPLETION; NOREPINEPHRINE TRANSPORTER; EXTRACELLULAR DOPAMINE;
D O I
10.1007/s00213-011-2576-x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
High levels of impulsivity are a core symptom of psychiatric disorders such as ADHD, mania, personality disorders and drug addiction. The effectiveness of drugs targeting dopamine (DA), noradrenaline (NA) and/or serotonin (5-HT) in the treatment of impulse control disorders emphasizes the role of monoaminergic neurotransmission in impulsivity. However, impulsive behavior is behaviorally and neurally heterogeneous, and several caveats remain in our understanding of the role of monoamines in impulse control. This study aims to investigate the role of DA, NA and 5-HT in two main behavioral dimensions of impulsivity. The effects of selective DA (GBR12909; 2.5-10 mg/kg), NA (atomoxetine; 0.3-3.0 mg/kg) and 5-HT (citalopram; 0.3-3.0 mg/kg) reuptake inhibitors as well as amphetamine (0.25-1.0 mg/kg) were evaluated on impulsive action in the five-choice serial reaction time task (5-CSRTT) and impulsive choice in the delayed reward task (DRT). In the 5-CSRTT, neuropharmacological challenges were performed under baseline and long intertrial interval (ITI) conditions to enhance impulsive behavior in the task. Amphetamine and GBR12909 increased impulsive action and perseverative responding and decreased accuracy and response latency in the 5-CSRTT. Atomoxetine increased errors of omission and response latency under baseline conditions in the 5-CSRTT. Under a long ITI, atomoxetine also reduced premature and perseverative responding and increased accuracy. Citalopram improved impulse control in the 5-CSRTT. Amphetamine and GBR12909, but not citalopram or atomoxetine, reduced impulsive choice in the DRT. Elevation of DA neurotransmission increases impulsive action and reduces impulsive choice. Increasing NA or 5-HT neurotransmission reduces impulsive action.
引用
收藏
页码:313 / 326
页数:14
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