Effects of maternal separation on hypothalamic-pituitary-adrenal responses, cognition and vulnerability to stress in adult female rats

被引：159

作者：

Aisa, B. ^{[1
]}

Tordera, R. ^{[1
]}

Lasheras, B. ^{[1
]}

Del Rio, J. ^{[1
]}

Ramirez, M. J. ^{[1
]}

机构：

[1] Univ Navarra, Sch Med, Dept Pharmacol, Pamplona 31008, Spain

来源：

NEUROSCIENCE | 2008年 / 154卷 / 04期

关键词：

forced swimming test; novel object recognition test; elevated plus maze; glucocorticoid receptor; mifepristone; propranolol;

D O I：

10.1016/j.neuroscience.2008.05.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the long term effects of neonatal stress in female rats and subsequent responses to stress when adults. Female rats that experienced maternal separation (MS) showed in adulthood depressive-like behavior in the forced swimming test and cognitive impairments in the novel object recognition test, which were reverted by the glucocorticoid receptor antagonist mifepristone or the beta-adrenoceptor antagonist propranolol. Markers of HPA axis (corticosterone levels, CRF mRNA levels in the paraventricular nucleus and glucocorticoid receptor density in the hippocampus) were altered by MS, suggesting that an altered HPA axis function may be associated to behavioral and cognitive deficits in MS female rats. In addition, MS rats were found to be more vulnerable to chronic stress than controls as shown by decreases in open field activity, increases in immobility time in the forced swim test, and changes in markers of HPA axis (decreases in the density of glucocorticoid receptors). These present findings are discussed in terms of gender differences in adulthood. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：1218 / 1226

页数：9

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