Cross-Dehydrogenative Coupling Reactions by Transition-Metal and Aminocatalysis for the Synthesis of Amino Acid Derivatives

被引：236

作者：

Xie, Jin ^{[1
]}

Huang, Zhi-Zhen ^{[1
,2
]}

机构：

[1] Nanjing Univ, Coll Chem & Chem Engn, Key Lab Mesoscop Chem, MOE, Nanjing 210093, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 52期

基金：

中国国家自然科学基金;

关键词：

amino acids; C-H activation; cooperative catalysis; cross-coupling; organocatalysis; C-H BONDS; CATALYZED OXIDATIVE CYANATION; MANNICH-TYPE REACTION; HYDROGEN-PEROXIDE; TERTIARY-AMINES; GLYCINE DERIVATIVES; ALLYLIC ALKYLATION; SODIUM-CYANIDE; BENZYL ETHERS; ARYL HALIDES;

D O I：

10.1002/anie.201004940

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct approach: The title coupling reactions of N-aryl glycine esters with unmodified ketones occurred smoothly in the presence of tert-butyl hydroperoxide (TBHP) or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) under mild conditions (see scheme). The oxidant used for C-H activation determined the selectivity of the reactions for a particular type of ketone substrate. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：10181 / 10185

页数：5

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