Ru-catalyzed anti-markovnikov addition of amides to alkynes: A regio- and stereoselective synthesis of enamides

被引：107

作者：

Goossen, LJ ^{[1
]}

Rauhaus, JE ^{[1
]}

Deng, GJ ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 26期

关键词：

alkynes; amides; enamides; homogeneous catalysis; hydroamidation; ruthenium;

D O I：

10.1002/anie.200462844

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The base-free anti-Markovnikov addition of secondary amides, anilides, lactams, ureas, bislactams, and carbamates to terminal alkynes is accomplished, for the first time, by a ruthenium-catalyzed reaction. Two complementary protocols provide stereoselective synthetic entries to either the E or the Z isomers (see scheme; cod = cycloocta-1,5-diene; DMAP = 4-(N,N-dimethylamino)pyridine). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4042 / 4045

页数：4

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