Telomere dynamics in hematopoietic stem cells

被引：13

作者：

Zimmermann, S ^{[1
]}

Martens, UM ^{[1
]}

机构：

[1] Univ Freiburg, Ctr Med, Dept Hematol Oncol, D-79106 Freiburg, Germany

来源：

CURRENT MOLECULAR MEDICINE | 2005年 / 5卷 / 02期

关键词：

D O I：

10.2174/1566524053586608

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The hematopoietic system has an outstanding regenerative capacity which depends on a relatively small population of hematopoietic stem cells (HSC). In contrast to normal human cells, blood-forming stem cells, like most of their counterparts from other adult tissues, exhibit telomerase activity to a certain level. Nevertheless, this telomerase activity does not prevent telomere shortening in HSC, suggesting a restriction of their proliferative capacity. Here, we review recent studies on telomere dynamics in HSC of humans and mice. Furthermore, we discuss the impact of telomere manipulation in HSC for possible clinical applications and speculate on functions of telomerase beyond telomere lengthening.

引用

页码：179 / 185

页数：7

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