Cytokine expression in the mouse brain in response to immune activation by Corynebacterium parvum

被引：19

作者：

Sheng, WS

Hu, S

Ding, JM

Chao, CC

Peterson, PK

机构：

[1] Minneapolis Med Res Fdn, Inst Brain & Immune Disorders, NeuroImmunol Lab, Minneapolis, MN 55404 USA

[2] Univ Minnesota, Sch Med, Minneapolis, MN 55404 USA

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2001年 / 8卷 / 02期

关键词：

D O I：

10.1128/CDLI.8.2.446-448.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokine expression in the brain has been suggested to mediate various sickness behaviors. Here we report that intraperitoneal injection of a Corynebacterium parvum antigen in C57BL/6 mice was followed by prolonged upregulation of cytokines in the cerebral cortex and subcortical structures in a time course that coincided with reduced spontaneous running activity.

引用

页码：446 / 448

页数：3

共 12 条

[1] IMMUNOLOGICALLY MEDIATED FATIGUE - A MURINE MODEL [J].

CHAO, CC ;

DELAHUNT, M ;

HU, SX ;

CLOSE, K ;

PETERSON, PK .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1992, 64 (02) :161-165

[2]

CHEMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156

[3]

Dantzer R, 1999, ADV EXP MED BIOL, V461, P83

[4] Molecular basis of sickness behavior [J].

Dantzer, R ;

Bluthé, RM ;

Gheusi, G ;

Cremona, S ;

Layé, S ;

Parnet, P ;

Kelley, KW .

MOLECULAR MECHANISMS OF FEVER, 1998, 856 :132-138

[5] Cytokines and sickness behavior [J].

Dantzer, R ;

Bluthé, RM ;

Layé, S ;

Bret-Dibat, JL ;

Parnet, P ;

Kelley, KW .

NEUROIMMUNOMODULATION: MOLECULAR ASPECTS, INTEGRATIVE SYSTEMS, AND CLINICAL ADVANCES, 1998, 840 :586-590

[6] THE CHRONIC FATIGUE SYNDROME - A COMPREHENSIVE APPROACH TO ITS DEFINITION AND STUDY [J].

FUKUDA, K ;

STRAUS, SE ;

HICKIE, I ;

SHARPE, MC ;

DOBBINS, JG ;

KOMAROFF, A ;

SCHLUEDERBERG, A ;

JONES, JF ;

LLOYD, AR ;

WESSELY, S ;

GANTZ, NM ;

HOLMES, GP ;

BUCHWALD, D ;

ABBEY, S ;

REST, J ;

LEVY, JA ;

JOLSON, H ;

PETERSON, DL ;

VERCOULEN, JHMM ;

TIRELLI, U ;

EVENGARD, B ;

NATELSON, BH ;

STEELE, L ;

REYES, M ;

REEVES, WC .

ANNALS OF INTERNAL MEDICINE, 1994, 121 (12) :953-959

[7]

GABELICA Z, 1995, P 8 SEM BRAS CAT AN, V1, P1

[8] BIOLOGICAL BASIS OF THE BEHAVIOR OF SICK ANIMALS [J].

HART, BL .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1988, 12 (02) :123-137

[9] PERIPHERAL ADMINISTRATION OF LIPOPOLYSACCHARIDE INDUCES THE EXPRESSION OF CYTOKINE TRANSCRIPTS IN THE BRAIN AND PITUITARY OF MICE [J].

LAYE, S ;

PARNET, P ;

GOUJON, E ;

DANTZER, R .

MOLECULAR BRAIN RESEARCH, 1994, 27 (01) :157-162

[10] Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition [J].

Maier, SF ;

Watkins, LR .

PSYCHOLOGICAL REVIEW, 1998, 105 (01) :83-107

← 1 2 →