Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

被引：723

作者：

Bernardi, Rosa ^{[1
]}

Pandolfi, Pier Paolo ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Beth Israel Deaconess Canc Ctr, Harvard Med Sch, Dept Med,Canc Genet Program, Boston, MA 02215 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2277

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.

引用

页码：1006 / 1016

页数：11

共 124 条

[61] Jiang WQ, 1997, CELL GROWTH DIFFER, V8, P513
[62] Covalent modification of PML by the sentrin family of ubiquitin-like proteins
Kamitani, T
Nguyen, HP
Kito, K
Fukuda-Kamitani, T
Yeh, ETH
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (06) : 3117 - 3120
[63] Cell cycle-dependent association of PML bodies with sites of active transcription in nuclei of mammalian cells
Kiesslich, A
von Mikecz, A
Hemmerich, P
[J]. JOURNAL OF STRUCTURAL BIOLOGY, 2002, 140 (1-3) : 167 - 179
[64] KOKEN MHM, 1995, ONCOGENE, V10, P1315
[65] Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus
Kumar, Pavan P.
Bischof, Oliver
Purbey, Prabhat Kumar
Notani, Dimple
Urlaub, Henning
Dejean, Anne
Galande, Sanjeev
[J]. NATURE CELL BIOLOGY, 2007, 9 (01) : 45 - U57
[66] Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
Kurki, S
Latonen, L
Laiho, M
[J]. JOURNAL OF CELL SCIENCE, 2003, 116 (19) : 3917 - 3925
[67] Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor α degradation
Lallemand-Breitenbach, V
Zhu, J
Puvion, F
Koken, M
Honoré, N
Doubeikovsky, A
Duprez, E
Pandolfi, PP
Puvion, E
Freemont, P
de Thé, H
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (12) : 1361 - 1371
[68] Alteration of the PML proto-oncogene in leukemic cells does not abrogate expression of MHC class I antigens
Larghero, J
Zassadowski, F
Rousselot, P
Padua, RA
Degos, L
Chomienne, C
[J]. LEUKEMIA, 1999, 13 (08) : 1295 - 1296
[69] Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors
Lin, Ding-Yen
Huang, Yen-Sung
Jeng, Jen-Chong
Kuo, Hong-Yi
Chang, Che- Chang
Chao, Ting-Ting
Ho, Chun-Chen
Chen, Yun-Ching
Lin, Tong-Ping
Fang, Hsin-I
Hung, Chih-Chang
Suen, Ching-Shu
Hwang, Ming-Jing
Chang, Kun-Sang
Maul, Gerd G.
Shih, Hsiu-Ming
[J]. MOLECULAR CELL, 2006, 24 (03) : 341 - 354
[70] Cytoplasmic PML function in TGF-β signalling
Lin, HK
Bergmann, S
Pandolfi, PP
[J]. NATURE, 2004, 431 (7005) : 205 - 211

← 2 3 4 5 6 7 8 9 10 11 →