Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study

被引:118
作者
Laakso, M. [2 ]
Zilinskaite, J. [2 ]
Hansen, T. [3 ]
Boesgaard, T. Wellov [3 ]
Vanttinen, M. [2 ]
Stancakova, A. [2 ]
Jansson, P. -A. [4 ]
Pellme, F. [4 ]
Holst, J. J. [5 ]
Kuulasmaa, T. [2 ]
Hribal, M. L. [6 ]
Sesti, G. [6 ]
Stefan, N. [7 ]
Fritsche, A. [7 ]
Haring, H. [7 ]
Pedersen, O. [3 ]
Smith, U. [1 ,4 ]
机构
[1] Sahlgrens Univ Hosp, Dept Mol & Clin Med, Lundberg Lab Diabet Res, S-41345 Gothenburg, Sweden
[2] Univ Kuopio, Dept Med, SF-70210 Kuopio, Finland
[3] Steno Diabet Ctr, DK-2820 Gentofte, Denmark
[4] Gothenburg Univ, Sahlgrenska Acad, Dept Mol & Clin Med, Lundberg Lab Diabet Res, Gothenburg, Sweden
[5] Univ Copenhagen, Dept Biomed Sci, Copenhagen, Denmark
[6] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Catanzaro, Italy
[7] Univ Tubingen, Dept Internal Med, Div Endocrinol Diabetol Nephrol Vasc Med & Clin C, D-7400 Tubingen, Germany
关键词
gastric inhibitory polypeptide; glucagon-like peptide-1; glucose; insulin; insulin release; insulin sensitivity; offspring; type; 2; diabetes;
D O I
10.1007/s00125-007-0899-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims/hypothesis We examined the phenotype of individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) with regard to insulin release and insulin resistance. Methods Non-diabetic offspring (n = 874; mean age 40 +/- 10.4 years; BMI 26.6 +/- 4.9 kg/m(2)) of type 2 diabetic patients from five different European Centres (Denmark, Finland, Germany, Italy and Sweden) were examined with regard to insulin sensitivity (euglycaemic clamps), insulin release (IVGTT) and glucose tolerance (OGTT). The levels of glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) were measured during the OGTT in 278 individuals. Results Normal glucose tolerance was found in 634 participants, while 110 had isolated IFG, 86 had isolated IGT and 44 had both IFG and IGT, i.e. about 28% had a form of reduced glucose tolerance. Participants with isolated IFG had lower glucose-corrected first-phase (0-10 min) and higher second-phase insulin release (10-60 min) during the IVGTT, while insulin sensitivity was reduced in all groups with abnormal glucose tolerance. Similarly, GLP-1 but not GIP levels were reduced in individuals with abnormal glucose tolerance. Conclusions/interpretation The primary mechanism leading to hyperglycaemia in participants with isolated IFG is likely to be impaired basal and first-phase insulin secretion, whereas in isolated IGT the primary mechanism leading to postglucose load hyperglycaemia is insulin resistance. Reduced GLP-1 levels were seen in all groups with abnormal glucose tolerance and were unrelated to the insulin release pattern during an IVGTT.
引用
收藏
页码:502 / 511
页数:10
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