Spectroscopic signatures of gas-phase helices:: Ac-Phe-(Ala)5-Lys-H+ and Ac-Phe-(Ala)10-Lys-H+

被引：108

作者：

Stearns, Jaime A. ^{[1
]}

Boyarkin, Oleg V. ^{[1
]}

Rizzo, Thomas R. ^{[1
]}

机构：

[1] EPFL SB ISIC LCPM, CH-1015 Lausanne, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 45期

关键词：

D O I：

10.1021/ja076507s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We apply gas-phase double resonance spectroscopic techniques to two helical peptides, Ac-Phe-(Ala)(5)-Lys-H+ and Ac-Phe-(Ala)(10)-Lys-H+, using electrospray ionization combined with photofragmentation in a cold, 22-pole ion trap. Despite the large size of the molecules, the electronic and infrared spectra are sharp, allowing us to identify transitions in the ultraviolet spectra associated with individual conformers, and to assign vibrations in the infrared spectra to local-mode N-H oscillators. We establish the spectral features in the infrared that are associated with the formation of gas-phase helices.

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页码：13820 / +

页数：3

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