Spectroscopic evidence for the formation of helical structures in gas-phase short peptide chains

被引：47

作者：

Brenner, Valerie ^{[1
]}

Piuzzi, Francois ^{[1
]}

Dimicoli, Iliana ^{[1
]}

Tardivel, Benjamin ^{[1
]}

Mons, Michel ^{[1
]}

机构：

[1] CEA Saclay, Serv Photons Atomes & Mol, URA CEA CNRS 2453, Lab Francis Perrin, F-91191 Gif Sur Yvette, France

来源：

JOURNAL OF PHYSICAL CHEMISTRY A | 2007年 / 111卷 / 31期

关键词：

D O I：

10.1021/jp070681l

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Aminoisobutyric acid (Aib) is a synthetic amino acid known to favor the formation of 3(10) helical structures in condensed phases, namely, crystals. The intrinsic character of these helicogenic properties has been investigated on the Ac-Aib-Phe-Aib-NH2 molecule under isolated conditions, namely, in the gas phase, both experimentally by double-resonance IR/UV spectroscopy and theoretically by quantum chemistry. A convergent set of evidence, based on energetic, IR, and UV spectroscopic data as well as on analogies with the similar peptide Ac-Ala-Phe-Ala-NH2 previously studied, enables us to conclude the formation of an incipient 3(10) helix in these isolated systems.

引用

页码：7347 / 7354

页数：8

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[1] Conformational analysis of cyclo( Phe-Ser) by UV-UV and IR-UV double resonance spectroscopy and ab initio calculations [J].

Abo-Riziq, AG ;

Crews, B ;

Bushnell, JE ;

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[2] Gas phase spectroscopy of the pentapeptide FDASV [J].

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CHEMICAL PHYSICS LETTERS, 2006, 431 (4-6) :227-230

[3] Spectroscopy of isolated gramicidin peptides [J].

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[4] Conformational properties of alpha-amino acids disubstituted at the alpha-carbon [J].

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[5] Folding structures of isolated peptides as revealed by gas-phase mid-infrared spectroscopy [J].

Bakker, JM ;

Plützer, C ;

Hünig, I ;

Häber, T ;

Compagnon, I ;

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Meijer, G ;

Kleinermanns, K .

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[6] Fingerprint IR spectroscopy to probe amino acid conformations in the gas phase [J].

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[7] LINEAR OLIGOPEPTIDES. 81. SOLID-STATE AND SOLUTION CONFORMATION OF HOMOOLIGO(ALPHA-AMINOISOBUTYRIC ACIDS) FROM TRIPEPTIDE TO PENTAPEPTIDE - EVIDENCE FOR A 310 HELIX [J].

BENEDETTI, E ;

BAVOSO, A ;

DIBLASIO, B ;

PAVONE, V ;

PEDONE, C ;

CRISMA, M ;

BONORA, GM ;

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[8] Conformational analysis of small peptides of the type Ac-X-NHMe, where X = Gly, Ala, Aib and Cage [J].

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Catalan, JG ;

Kruger, H ;

Perez, JJ .

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[9] Chirality-controlled formation of β-turn secondary structures in short peptide chains:: Gas-phase experiment versus quantum chemistry [J].

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[10] Gas-phase models of γ turns:: Effect of side-chain/backbone interactions investigated by IR/UV spectroscopy and quantum chemistry -: art. no. 084301 [J].

Chin, W ;

Piuzzi, F ;

Dognon, JP ;

Dimicoli, I ;

Mons, M .

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