Polyvalent Nucleic Acid/Mesoporous Silica Nanoparticle Conjugates: Dual Stimuli-Responsive Vehicles for Intracellular Drug Delivery

被引：276

作者：

Chen, Cuie ^{[1
,2
,3
]}

Geng, Jie ^{[1
,2
,3
]}

Pu, Fang ^{[1
,2
,3
]}

Yang, Xinjian ^{[1
,2
,3
]}

Ren, Jinsong ^{[1
,2
,3
]}

Qu, Xiaogang ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, State Key Lab Rare Earth Resources Utilizat, Changchun Inst Appl Chem, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Biol Chem Lab, Changchun Inst Appl Chem, Changchun 130022, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 04期

基金：

中国国家自然科学基金;

关键词：

click chemistry; DNA; drug delivery; mesoporous materials; nanoparticles; MESOPOROUS SILICA; CONTROLLED-RELEASE; GUEST MOLECULES; CLICK CHEMISTRY; GOLD NANOPARTICLES; CANCER-CELLS; NANOVALVES; DNA; SYSTEM; FUNCTIONALIZATION;

D O I：

10.1002/anie.201005471

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Blocked tubes: Attachment of self-complementary duplex DNA to the openings of mesoporous silica nanoparticles results in a cap for trapping guest molecules. The cargo can be released either by thermal stimuli or by the introduction of DNase I, both of which open the capping DNA structure (see picture). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：882 / 886

页数：5

共 51 条

[1] DNA duplex-quadruplex exchange as the basis for a nanomolecular machine [J].