Enzyme-Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose

被引：213

作者：

Bernardos, Andrea ^{[1
,2
]}

Aznar, Elena ^{[1
]}

Dolores Marcos, Maria ^{[1
]}

Martinez-Manez, Ramon ^{[1
]}

Sancenon, Felix ^{[1
]}

Soto, Juan ^{[1
]}

Manuel Barat, Jose ^{[2
]}

Amoros, Pedro ^{[3
]}

机构：

[1] Univ Politecn Valencia, Dept Quim, Univ Valencia,Ctr Mixto, Inst Reconocimiento Mol & Desarrollo Tecnol, Valencia 46022, Spain

[2] Univ Politecn Valencia, Inst Ingn Alimentos Desarrollo, Valencia 46022, Spain

[3] Univ Valencia, Inst Univ Ciencia Mat ICMUV, Valencia 46071, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 32期

关键词：

carbohydrates; controlled release; enzymes; mesoporous materials; molecular devices; INORGANIC HYBRID MATERIALS; DRUG-DELIVERY; SUPRAMOLECULAR CHEMISTRY; GUEST MOLECULES; POLYMERS; NANOVALVES; SYSTEMS; NANOPARTICLES; SCAFFOLDINGS; ENSEMBLES;

D O I：

10.1002/anie.200900880

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The great escape: A biocontrolled gated material has been prepared by grafting a lactose derivative onto the pore outlets of a mesoporous support. The galactosidase-induced hydrolysis of the β1→4 glycosidic bond in the lactose moiety (red box in picture) allows the release of a dye entrapped in the pores of the hybrid material to the bulk solution. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5884 / 5887

页数：4

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