Paradoxical inflammatory reaction during treatment of Cryptococcus neoformans var. gattii meningitis in an HIV-seronegative woman

被引：54

作者：

Einsiedel, L ^{[1
]}

Gordon, DL ^{[1
]}

Dyera, JR ^{[1
]}

机构：

[1] Flinders Med Ctr, Dept Microbiol & Infect Dis, Bedford Pk, SA, Australia

来源：

CLINICAL INFECTIOUS DISEASES | 2004年 / 39卷 / 08期

关键词：

D O I：

10.1086/424746

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A human immunodeficiency virus (HIV)-seronegative woman was admitted to the hospital with postpartum onset Cryptococcus neoformans var. gattii meningitis and markedly increased intracranial pressure. A poor initial response to antifungal therapy was followed, 2 months after hospital admission, by severe acute meningeal and cerebral inflammation and clearance of yeast cells from cerebrospinal fluid. This first reported case of paradoxical inflammatory reaction to C. neoformans illustrates important aspects of the host-pathogen interaction and highlights possible effects of immunomodulatory therapies.

引用

页码：E78 / E82

页数：5

共 17 条

[11]

LOTHOLARLY O, 2001, J INFECT DIS, V183, P294

[12] KILLING OF CRYPTOCOCCUS-NEOFORMANS STRAINS BY HUMAN NEUTROPHILS AND MONOCYTES [J].

MILLER, MF ;

MITCHELL, TG .

INFECTION AND IMMUNITY, 1991, 59 (01) :24-28

[13] The host immune response to tuberculosis [J].

Schluger, NW ;

Rom, WN .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (03) :679-691

[14] Combination immunotherapy and antifungal chemotherapy [J].

Stevens, DA .

CLINICAL INFECTIOUS DISEASES, 1998, 26 (06) :1266-1269

[15] DOWN-REGULATION BY CRYPTOCOCCAL POLYSACCHARIDE OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA SECRETION FROM HUMAN MONOCYTES [J].

VECCHIARELLI, A ;

RETINI, C ;

PIETRELLA, D ;

MONARI, C ;

TASCINI, C ;

BECCARI, T ;

KOZEL, TR .

INFECTION AND IMMUNITY, 1995, 63 (08) :2919-2923

[16] Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes [J].

Vecchiarelli, A ;

Retini, C ;

Monari, C ;

Tascini, C ;

Bistoni, F ;

Kozel, TR .

INFECTION AND IMMUNITY, 1996, 64 (07) :2846-2849

[17] HIV combination therapy: partial immune restitution unmasking latent cryptococcal infection [J].

Woods, ML ;

MacGinley, R ;

Eisen, DP ;

Allworth, AM .

AIDS, 1998, 12 (12) :1491-1494

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