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Future of oncologic photodynamic therapy

被引：40
作者：
Allison, Ron R. [1 ]
Bagnato, Vanderlei S. [2 ]
Sibata, Claudio H. [3 ]
机构：
[1] 21st Century Oncol, Greenville, NC 27834 USA
[2] Univ Sao Paulo, Inst Fis, Sao Carlos, SP, Brazil
[3] Brody Sch Med, Dept Radiat Oncol, Greenville, NC 27834 USA
来源：
FUTURE ONCOLOGY | 2010年 / 6卷 / 06期
关键词：
future; photodynamic therapy; photosensitizer; FLUORESCENCE-GUIDED RESECTION; MALIGNANT BRAIN-TUMORS; 5-AMINOLEVULINIC ACID; PROTOPORPHYRIN-IX; NECK-CANCER; LUNG-CANCER; FOLLOW-UP; LIGHT; PDT; HEMATOPORPHYRIN;
D O I：
10.2217/FON.10.51
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Photodynamic therapy (PDT) is a tumor-ablative and function-sparing oncologic intervention. The relative simplicity of photosensitizer application followed by light activation resulting in the cytotoxic and vasculartoxic photodynamic reaction has allowed PDT to reach a worldwide audience. With several commercially available photosensitizing agents now on the market, numerous well designed clinical trials have demonstrated the efficacy of PDT on various cutaneous and deep tissue tumors. However, current photosensitizers and light sources still have a number of limitations. Future PDT will build on those findings to allow development and refinement of more optimal therapeutic agents and illumination devices. This article reviews the current state of the art and limitations of PDT, and highlight the progress being made towards the future of oncologic PDT.
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页码：929 / 940
页数：12
相关论文
共 87 条
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