Evaluation of seasonal influenza vaccination effectiveness based on antibody efficacy among the institutionalized elderly in Japan

被引：11

作者：

Hara, Megumi ^{[1
]}

Tanaka, Keitaro ^{[1
]}

Kase, Tetsuo ^{[2
]}

Maeda, Akiko ^{[3
]}

Hirota, Yoshio ^{[3
]}

机构：

[1] Saga Univ, Dept Prevent Med, Fac Med, Saga 8498501, Japan

[2] Osaka Prefectural Inst Publ Hlth, Higashinari Ku, Osaka 5370025, Japan

[3] Osaka City Univ, Dept Publ Hlth, Fac Med, Abeno Ku, Osaka 5458585, Japan

来源：

VACCINE | 2010年 / 28卷 / 35期

关键词：

Influenza vaccine; Antibody efficacy; Elderly; PREVENTING HOSPITALIZATION; IMMUNE-RESPONSE; HEALTHY; IMMUNIZATION; VACCINES;

D O I：

10.1016/j.vaccine.2010.06.061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Influenza vaccination efficacy was evaluated in 114 institutionalized elderly people in 2002/03. Strain A/H3N2 was isolated, 44 and 8 subjects had sudden-onset fever (>= 37.8 degrees C) and kit-diagnosed influenza, respectively Odds ratios adjusted for age, sex, comorbidity, and vaccine strain (OR(adj)) were determined using multiple logistic regression. Seroprotected patients (haemagglutination-inhibition antibody titre >= 1:40) had lower incidence of fever (OR(adj), 035: 95% confidence Interval [CI] 0.09-1.28) and kit-diagnosed influenza (OR(adj), 0.35, 95% CI, 0.03-4.64) than patients without seroprotection (antibody efficacy, similar to 65%). Seroprotective levels of vaccination-Induced antibodies probably prevent influenza among the institutionalized elderly, although statistical significance could not be confirmed owing to the sample size (C) 2010 Elsevier Ltd. All rights reserved

引用

页码：5664 / 5668

页数：5

共 21 条

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